Asthma Flashcards

1
Q

Asthma

A

chronic inflammatory disorder of the airways

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2
Q

Chronic

A

persistent/ long lasting symptoms. Usually lasts for more than three months.

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3
Q

Asthma is know as a what type of condition?

A

heterogenous condition which means there are many factors which cause it.

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4
Q

Asthma prevalence

A

an estimate of the percentage of the US population with asthma.

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5
Q

Asthma period prevalance

A

the percentage of the population that had asthma in the previous 12 months

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6
Q

NACP National asthma control program

A

helps millions gain control over their disease

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7
Q

Which groups are more likely to have asthma?

A

the black population/ lower income groups/ older women/ younger men

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8
Q

Symptoms of Asthma

A

Repeated episodes of wheezing
Breathlessness.
Chest tightness.
Nighttime or early morning coughing.

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9
Q

What are the four classifications of asthma?

What are the different types of allergen testing?

A

mild intermittent
mild persistent
moderate persistent
severe persistent

scratch- scratch to let the allergen on the surface of skin in.
intradermal- inject just below the skin
patch- place patch on the skin.

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10
Q

mild intermittent

A

symptoms do not occur on a consistent basis and can go through long periods of time with out symptoms

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11
Q

Mild persistent

A

coughing, wheezing, chest tightness 3-6 times a week,

waking up at night coughing.

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12
Q

moderate persistent

A

daily symptoms may cause night time awakening

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13
Q

severe persistent

A

continuous symptoms and wake up regularly at night to asthma

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14
Q

for those with asthma what are the changes in respiratory passages?

A

airways become inflamed with swelling of the bronchial mucous membrane and secretion of excessive thick mucus that is difficult to expel.

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15
Q

What causes asthma

A

gene-by environment interactions
atopy
viral respiratory infections
smoking during pregnancy

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16
Q

Name five asthma triggers

A
pollen 
bugs in the home
smoke 
pollution 
pets
17
Q

the concepts of underlying asthma pathogenesis

A

inflammation
airway hyper-responsiveness
air ways obstruction
clinical symptoms

18
Q

What are the cells involved in asthma

A
dendritic cells
neutrophils
eosinophils
t lymphocytes 
mast cell activation
macrophages
19
Q

dendritic cells

A

antigen presenting cells which interacts with allergens from the airway surface, migrate to regional lymph nodes and stimulate Th2 cell production

20
Q

neutrophils

A

appears during sudden onset or fatal asthma exacerbations

21
Q

eosinophils

A

generates leukotrienes and express a wide variety of cytokines

22
Q

T lymphocytes

A

lead to overproduction of igE antibodies, eosinophils activation, and airway hyperresponsiveness

23
Q

mast cell activation

A

releases histamines and prostaglandin D2

24
Q

macrophage

A

releases inflammatory mediators that amplify the inflammatory response