lecture 13- prenatal development Flashcards
Phylogenetic continuity
- We are just another type of animal
- Due to our shared evolutionary history, we share many characteristics and developmental processes with other living things
Brain structure and function
- The size of human brain is markedly larger and more complex than other mammals
- Scientists have a long-standing interest in the genetics underpinning development of the human brain
Homo sapiens
- Principles of cortical development are similar in mouse, macaque and human brain
- Functions of neurotransmitters, receptors and ion channels do not change substantially over phylogenetic scale
- Secret to success of human? Possibly increased number of neurons, more elaborate connections and functional specialisation of cortical areas
gametes
- Sperm and ova are uniqugae cells in the human body as they contain only half the chromosomes of the somatic cells, via meiosis
- Reduction to 23 chromosomes allows for the merging of the sperm and ovum into one new being with 46 chromosomes
- The ovum is the largest cell in the human body and is released from one of the ovaries into the fallopian tube
- It releases a chemical signal to any awaiting sperm
gametes continued
-During ejaculation, as many as 500 million sperm are produced
-Each sperm has a pointed head packed with genetic information and a long tail that whips the sperm along
-The sperm must travel ~ 6 hours (6-7 inches) from the vagina through uterus to the fallopian tube
Only about 200 ever get close to the ovum
Being a bloke is hard
- Sperm carrying the lighter & chromosomes are lighter and swim faster
- This vulnerability continues through life
- Boys are more likely to suffer from developmental disorders (autism, ADHD, dyslexia, schizophrenia, mental retardation)
- Adolescent boys are more impulsive than girls on average, and take more risks
- More likely to commit suicide, die violently
- Eventually, men die earlier than women, on average
Periods of prenatal development
Prenatal development is often divided into three major phases:
period of the zygote
- 0 to 14 days
- From conception to implantation into the wall of the uterus
Period of the embryo
3 to 8 weeks
Virtually all the major organs are formed
Period of the fetus
9th week until birth
All the major functions begin to function and the developing organism grows
The zygote
- The winning sperm penetrates the outer membrane of the ovum
- A chemical reaction seals the membrane, preventing other sperm from entering
- Tail of sperm falls off, contents of head gush into ovum and within hours the nuclei of the two gametes merge, producing the zygote
- Within 12 hours of fertilisation, the zygote splits into two equal parts, each containing a full set of genetic material. This process is called…..
Blastocyst
- The two cells then divide into four, then eight, then sixteen and so on
- Over the course of the next 38 weeks, the single celled organism will be born as a person with trillions of cells
- The blastocyst is a ball-like structure that contains 60-80 cells, within 4 days of conception
- Implantation of the zygote into the uterine wall occurs between 8 and 14 days from conception
- The zygote develops small, burr-like tendrils, that emerge from its outer surface
- When the blastocyst reaches the uterine wall, these tendrils burrow inward, tapping the woman’s blood supply (implantation)
- Only half of all fertilised ova are firmly implanted
- Perhaps as many as half of all such implants are genetically abnormal or fail to develop, or burrow into a site incapable of sustaining them
- ¾ of zygotes fail to survive this initial phase of development
Embryo
- The embedded balls of cells begin to differentiate
- The inner cell mass will become the embryo and the rest of the cells will become the amniotic sac and placenta
Four major support structures
- Once implanted, the blastocyst’s outer layer forms four major support structures that protect and nourish the developing embryo
- Amnion is a watertight sac that fills with fluid, acting as a cushion, regulating temperature and providing a weightless environment
- Chorion is a membrane surrounding the amnion, and it eventually becomes the lining of the placenta
- Allantois forms the umbilical cord
the placenta
- The placenta is a support organ for the developing organism
- It keeps the circulatory systems of the embryo/fetus and mother separate, but a semi-permeable membrane permits oxygen and nutrients from the mother and carbon dioxide and waste from the fetus, via the umbilical cord