Lecture 12- Contributions Of Cerebellum And Basal Nuclei To Motor Function I Flashcards

1
Q

What does the premotor cortex (area6) do?

A
  • Plans movements based on sensory and visual cues
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2
Q

What does the supplementary motor area (area6) do?

A
  • retrieves and coordinates memorized motor sequences
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3
Q

What are some functions of the motor cortex system (4)?

A
  • provides most of the activating signals to the spinal cord
  • Issues sequential and parallel commands that initiate various cord patterns
  • cortical patterns are usually complex and can be learned
  • cord patterns are mainly determined by heredity and are “hard-wired”
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4
Q

Why has the cerebellum been called a silent area of the brain?

A

Because electrical excitation of the cerebellum modes not cause any conscious sensation and rarely causes any motor movement

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5
Q

Removal of the cerebellum causes what?

A

Causes body movements to become highly abnormal

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6
Q

What are the two major roles played by the cerebellum?

A
  • timing of motor activities

- rapid, smooth progression from one muscle movement to the next

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7
Q

What are some of the functions of the cerebellum (12)?

A
  • it is not essential for locomotion
  • it helps sequence motor activities
  • it monitors and makes corrective adjustments to motor activities while they are being executed
  • it compares actual movements with intended movements
  • It aids the cortex in planning the next sequential movement(s)
  • it learns by its mistakes
  • It functions with the spinal cord to enhance the stretch reflex
  • it functions with the brain stem to make postural movements
  • it functions with the cerebral cortex to provide accessory motor functions
  • it turns on the antagonist at the appropriate time
  • it helps program muscle contraction in advance
  • it functions mainly when muscle movements have to be rapid
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8
Q

What are the three lobes of the cerebellum?

A
  • anterior lobe
  • posterior lobe
  • flocculonodular lobe
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9
Q

Which of the lobes to the cerebellum is associated with the vestibular system?

A

Flocculonodular lobe

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10
Q

What is the function of the vermis?

A

Location for control functions for muscle movements of the axial body, neck, shoulders, and hips

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11
Q

What is the function of the intermediate zone?

A

It is concerned with controlling muscle contractions in the distal portions of the upper and lower limbs, especially hands, feet, fingers, and toes.

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12
Q

What is the function of the lateral zone?

A

Associated with cerebral cortex with planning of sequential motor movements

  • without this lateral zone, most discrete motor activities of the body lose their appropriate timings and sequencing and therefore become uncoordinated
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13
Q

Describe the cortex of the cerebellum.

A
  • like the cerebral cortex, this is gray matter and consists of multiple layers of cells, dendrites, and synapses
  • consists of transversely arranged narrow gyro called folia
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14
Q

The intracerebellar nuclei make up an inner layer of greater matter in the cerebellum. What are the following pairs of nuclei does it contain?

A
  • dentate
  • emboliform
  • globose
  • fastigial
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15
Q

All of the deep cerebellar (intracerebellar) nuclei receive signals from what two sources?

A
  • cerebellar cortex

- the deep sensory afferent tracts to the cerebellum

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16
Q

What are some characteristics of the dentate nuclei, emboliform nuclei, and the glob use nuclei (3)?

A
  • lesions in these nuclei lead to extremity ataxia
  • these fibers project to the red nucleus
  • related to limb musculature and fine manipulative movement
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17
Q

What are some characteristics of the fastigial nuclei (3)?

A
  • lesions in this nuclei results in I trunk ataxia
  • fibers project to reticular formation and vestibular nuclei
  • related to postural activity and limb movements via reticulospinal and vestibulospinal tracts
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18
Q

Two areas of gray matter in the cerebellum?

A
  • cortex

- intracerebellar nuclei (deep cerebellar nuclei)

19
Q

What’s are the layers of the cerebellar cortex?

A
  • granular layer
  • purkinje cell layer
  • molecular layer
20
Q

Granular layer?

A
  • inner most layer
  • made up of granule cells, Golgi type II cells, and glomeruli
  • axons of mossy fibers synapse with granular cells and Golgi type II cells in the glomeruli
21
Q

Purkinje cell layer?

A
  • middle layer

- contains Purkinje cells

22
Q

Molecular layer?

A
  • outer most layer
  • contains stellar cells, basket cells, Purkinje dendrites, Golgi type II cells, and axons of granule cells (parallel fibers)
23
Q

These are the only excitatory cell in the cerebellar cortex?

A

Granular cells

24
Q

Granular cells?

A
  • axons form parallel fibers in cortex (+)
25
Q

Golgi cells?

A
  • project from parallel fibers to granular cell bodies (-)
26
Q

Basket cells?

A
  • Project from parallel fibers to Purkinje axon hillock (-)
27
Q

Stellate cells?

A
  • Project from parallel fibers to Purkinje dendrites (-)
28
Q

Both of the cells types are located in the molecular level of the cerebellar cortex?

A
  • Basket cells

- Stellate cells

29
Q

These cells provide lateral inhibition on adjacent Purkinje cells to provide damping?

A
  • basket cells and stellar cells
30
Q

Purkinje cells (5)?

A
  • extensive dendritic branching
  • receive input from parallel fibers (20,000 synapses between parallel fibers and one Purkinje cell
  • project to intracerebellar nuclei (-)
  • ONLY output from cortex
  • output is ALWAYS INHIBITORY
31
Q

Cerebellar cortex afferent pathways?

A
  • climbing fibers

- mossy fibers

32
Q

Climbing fibers(5)?

A
  • originate from medullary olives
  • make multiple synapses with Purkinje cells
  • Provide high frequency bursts (complex spikes)
  • “condition” the Purkinje cells
  • play a role in motor learning
33
Q

Mossy fibers (3)?

A
  • originate from multiple centers in the brainstem and spinal cord, including vestibulocerebellar, spinocerebellar, and pontocerebellar tracts
  • make multiple synapses on Purkinje cells and result in simple spikes
  • synapse on granule cells in glomeruli
34
Q

Purkinje cell axons (5)?

A
  • the only output form the cerebellar cortex
  • output is ALWAYS INHIBITORY
  • GABA
  • Projects to deep cerebellar nuclei and vestibular nucleus
  • modulates output of cerebellum and provides synergy (regulates rate, range, and direction of movement)
35
Q

How many functional units are in the cerebellar cortex?

A

30 million

36
Q

Each functional unit of the cerebellar is centered on what?

A

A Purkinje cell and a deep nuclear cell

37
Q

What does the primary cortex (area 4) do?

A
  • signals motor neurons to contract skeletal muscle fibers
  • signals via the corticospinal (pyramidal) tract
  • execution of commands is preceded by extensive processing by the cerebellum and basal nuclei
38
Q

The output from a functional unit of the cerebellar cortex comes from where?

A

Deep nuclear cell

39
Q

Afferent inputs to the cerebellum are mainly from what?

A
  • climbing fibers

- mossy fibers

40
Q

Where do all climbing fibers originate?

A

Inferior olives

41
Q

The nervous system uses the cerebellum to coordinate motor control function at what three levels?

A
  • vestibulocerebellum
  • spinocerebellum
  • cerebrocerebellum
42
Q

What is the relationship of the vestibulocerebellum to pendular movements?

A
  • most body movements are pendulum (9swing back and forth)
  • all pendular movements tend to overshoot
  • appropriate learned subconscious signals from intact cerebellum can stop movement precisely at intended point (= damping system)
43
Q

What are some changes that occur when the cerebellum is removed?

A
  • movements are slow to develop
  • force developed is weak
  • movements are slow to turn off