Lecture 11: Respiration Acid-Base Balance Flashcards
Buffer
reduces changes in pH resulting from addition of strong acids or bases; decrease impact of excess h+ immediately available; don’t eliminate H+ from body
Properties of Buffers
Most resistant to changes in H+ when pH= K
Buffering ability of +/- 1 pH unit of pK
Strength directly relatedto concentration of buffer pair components
Buffers in the body
Phosphate buffer
protein buffer
Bicarb buffer
Phosphate Buffer
weak; pK= 6.8
Protein Buffer system
Uses Hb, most important blood borne protein buffer, pK= 5.3-8.3
Bicarb Buffer system
open system that removes acid by elimination into environment; directly regulated by the lungs (CO2 by ventilation) and kidneys (H+ by urination)
CO2
acid
HCO3
base
H+
free proton
CO2 and H+ are continuously removed from the body at the rate at which?
it is produced
This is used as a catalyst to slow the intial step
carbonic anhydrase
Extracellular blood pH
7.35-7.45
Extracelllular bood is regulated by?
Respitory, Renal and GI Tracts
which system has the largest release of CO2
Lungs
By increasing H+ you?
decrease pH (make more acidic)