Lecture 11: Host Defense III

Question 1

5 types of innate immune responses

Answer 1

1. Constitutional factors
2. Natural barriers and normal flora
3. Cytokines/interferons
4. Phagocytosis
5. Complement

Question 2

2 types of adaptive immune responses

Answer 2

1. Humoral

2. Cell mediated

Question 3

Cell mediated immunity is mediated by

Answer 3

Antigen-activated T cells and the cytokines they secrete

Question 4

In cell mediated immunity, CD8+ T cells function as

Answer 4

Cytotoxic T lymphocytes (CTL)

Question 5

In cell mediated immunity, CD4+ TH1 cells and activated macrophages function in what kind of response?

Answer 5

DTH (delayed type hypersensitivity) response

Question 6

How many classes of the major histocompatibility complex (MHC)?

Answer 6

Two:

MHC I and II

Question 7

MHC class I act on what?

Answer 7

All nucleated cells, including APCs

Question 8

MHC class II act on what?

Answer 8

Only APC’s (B cells, macrophages, and dendritic cells)

Question 9

Function of class 1 MHC

Answer 9

Present Ag to cyto-toxic T (CD8+) cells

Question 10

Function of class II MHC

Answer 10

Present Ag to T (CD4+) helper cells

Question 11

Result of class I MHC cells

Answer 11

T cell - mediated toxicity

Question 12

Result of class II MHC cells

Answer 12

T-cell mediated help

Question 13

CD8 cells are restricted by what

Answer 13

MHC I

Question 14

CD4 T cells are restricted by what?

Answer 14

MHC II

Question 15

What are the best APC to activate Naïve T cells?

Answer 15

conventional dendritic cells

Question 16

Conventional dendritic cells serve as a critical bridge between

Answer 16

innate and adaptive immunity

Question 17

Antibody dependent cell-mediated cytotoxicity (ADCC)

Answer 17

Cell-mediated immune defense whereby an effector cell actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies