LEcture 11 clocks and cancer

Question 1

Implications in cancer control

Answer 1

BMAL1:CLK down regulated c-myc(oncgene when mutated)
PER1 is seen to interact with ATM/CHK2- during the night when majority of cell damage happens - control in G1/S checkpoint
BMAL/CLK activate wee1

Question 2

Implications in cancer control
Control of the cell cycle
DNA damage repair

Answer 2

BMAL1:CLK down regulated c-myc(oncgene when mutated)
PER1 is seen to interact with ATM/CHK2- during the night when majority of cell damage happens-control in G1/S checkpoint
BMAL/CLK activate wee1

Question 3

Implications of distruption

Answer 3

tumour promoting inflammation
sustains proliferative signallying
genome instability and mutation