EGFR anf FGR

Question 1

points

Answer 1

Extracellular Domain of EGRF and FGF (3 IG like domains are different, involvement of HSPG (proto glycans)),
EGFR HER 2 has no head
Extracellular domain of EGFR high variation,
The intracellular kinase domain of FGF is similar to the VEGFR
cytoplasmic domains similar(FGFr cancer therapy targets have off target effects
Deregulation of FGFR.
Inactivation is similar-both endocytosed.

Question 2

EGFR cancer causes

Answer 2

Heterodimers of EGFR with HER2 may be particularly oncogenic because a) HER2 inhibits endocytosis of EGFRby blocking its ubiquitination and b) HER2 has many binding sites for PI 3-kinase

chromosonal translocation, gene amplification, impaired degradation

Question 3

what are the 4 pathways

Answer 3

Ras/Mapk, STAT, PLC-y pathway, PIP3K pathway

Question 4

Ras/MapK pathway

Answer 4

phospho-tyrosine recruits adaptor GRB2 which Recruits SOS
SOS activates RAS(on the membrane)
RAS-CRAS-RAF-ERK signalling cascade
actve ERK enters nucleus transcriptinal activates genes for cell division(cyclinD and cfos

Question 5

STAT pathway

Answer 5

STAT protein(adaptor) is a transcription factor for growth genes

Question 6

PLC-y pathway

Answer 6

PLC-y is recruited- acts on PIP2 on membrane- activates PKC targets promoters for cell division`

Question 7

PI3K pathway

Answer 7

PI3K recruited via p65 subunit, allows for activation of AKT- regulates pathways for cell cycle

Question 8

FGFR signalling

Answer 8

specfici adaptor protein FGRS2 is phophorylates
FGRS2 recruits GRB2&SOS pathway.
FGRS2 recruits GRB2&GAB1 to signal down the PI3K pathway