Lecture 10 Connective Tissue, Bone and Cartilage Flashcards
Connective Tissue
Embryonic
Adult
Special
Adult CT 4 Types
Loose
Dense
Reticular
Elastic
4 Types of Special CT
Adipose
Cartilage
Bone
Hematopoietic
Type 1 Collagen Fibers
General CT and bone
tensile strength
Type II Collagen
Hyaline and elastic cartilage
tensile strength
Type III collagen
Parenchyma of organs and walls of blood vessels
Reticular framework
Type IV collagen
Basement membranes
Meshwork, scaffolding
Collagen Fiber Synthesis
- Type I collagen is synthesized as a prepropeptide
- The signal (pre-) sequence is cleaved after the translocation of the polypeptide into the ER lumen
- Pro-collagen molecule is secreted through exocytosis
- Tropocollagen - after secreted, altered into this. This self-assembles into collagen
- Collagen
Elastic Fiber Synthesis
Elastin is also synthesized as a prepropeptide
Secreted as a propeptide
Converted to tropoelastin - final component of elastin assembly
Assembled into amorphous fibers or sheets with the aid of fibrillin
Tropoelastin
Final component of elastin assembly
Fibrillin
Assembles tropoelastin into amorphous fibers or sheets
Fibroblasts and fibrocytes
Principal cell types found in connective tissue. They are also most numerous cells found in CT
-secrete and maintain connective tissue
Secretion and maintenance of CT matrix
Secrete precursor fibrous molecules
Secrete the amorphous components of the matrix, including the glycosaminoglycans
Glycosaminoglycans
GAGs
Large, negatively charged polysaccharides consisting of repeated discaccharide units.
GAGs fall into 4 groups
- Hyaluronic acid (cartilage, skin, synovial fluid and general CT)
- Heparin and heparan sulfate
- Chondroitin sulfate and dermatan sulfate
- Keratan sulfate (cartilage, cornea and intervertebral disk)
Adipocytes
Fat cells 150 micrometers in diameter 2 Types 1. White fat 2. Brown fat