Lecture 1 Flashcards
what is innate immunity?
non-specific
what is adaptive immunity?
specific
what are the primary lymphoid organs?
thymus, bone marrow
what are the secondary lymphoid organs?
where the lymph nodes are activated e.g. lymph nodes, spleen, tonsils, payers patches
what are the tertiary lymphoid organs?
abnormal lymph node-like structures in peripheral tissues at sites of chronic inflammation
what do T cells start of as?
thymocytes
what happens when thymocytes proliferate?
96-99% die in the cortex and the rest move to the medulla
what gives receptor diversity in the thymus?
gene rearrangements
what are lymph nodes?
a network of phagocytotic and dendritic cells
what is the function of the spleen?
filters antigens from the blood
what could happen as a result of having no spleen?
sepsis
what are the functions of the skin that help protect from infection?
stratum corneum, glandular secretions, sebaceous layer, commensal bacteria
what is the stratum corneum?
outer layer of flat cells filled with keratin, acting as a physical barrier to invasion, abrasion and dehydration
how do glandular secretions work?
sweat glands produce lysozyme which degrades peptidoglycans
how does sebaceous surfaces work?
glands produce sebum containing unsaturated fatty acids