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HEMATOLOGY > [LEC] Rules of Maturation, Maturation Pools > Flashcards

[LEC] Rules of Maturation, Maturation Pools Flashcards

1
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND GRANULATION

A

INDIRECT
Cells lose their granules as they mature

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2
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND NUCLEUS

A

INDIRECT
Blast cells have the largest nucleus (3/8 to 7/8 of cell area)
and a SKANTY amount of cytoplasm

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3
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND CYTOPLASMIC BASOPHILIA

A

INDIRECT
DNA production decreases with maturation
DNA is made of amino ACIDS
Acid levels decrease
Attraction to blue stain also decreases

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4
Q

WHAT CELL IS EXEMPTED FROM THE RULE OF MATURATION REGARDING THE BASOPHILIA OF THE CYTOPLASM

A

PLASMA CELL
Basophilia will not decrease as it ages ????

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5
Q

WHAT IS THE COLOR OF A LEUKEMIC PATIENT’S BLOOD SMEAR AND WHAT RULE OF MATURATION IS RELATED TO IT

A

BLUE
In leukemia, there is an abundance of immature cells
Basophilia is a characteristic of immaturity in cells

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6
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND CHROMATIN

A

INDIRECT
As cells mature, the chromatin clumps more

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7
Q

MATCH THE CELL TO ITS CELLULAR CHARACTERISTIC

  1. Immature Cell
  2. Mature Cell

A. Closed Chromatin
B. Open Chromatin

A
  1. Immature — Open Chromatin
  2. Mature — Closed Chromatin

Recall that chromatin clumps more are maturity is obtained by the cell

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8
Q

[RULES OF MATURATION]
RELATIONSHIP OF CHROMATIN CLUMPING TO NUCLEUS SIZE

A

INDIRECT

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9
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND CHROMATIN STAINING

A

INDIRECT
The more aggregated the chromatin is, the darker they stain

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10
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND CELL SIZE

A

INDIRECT
Cellular components shrink, clump, and eventually cease to exist in the cell

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11
Q

WHICH CELL IS EXEMPT FROM THE CELL MATURATION RULE ABOUT SIZE

A

MEGAKARYOCYTE
It is the largest mature cell in the BM

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12
Q

WHAT IS THE LARGEST CELL IN THE BONE MARROW

A

MEGAKARYOCYTE

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13
Q

WHAT IS THE LARGEST CELL IN THE PERIPHERAL CIRCULATION

A

MONOCYTE

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14
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND APPEARANCE OF NUCLEOLI

A

INDIRECT
Chromatin pattern becomes more coarse and condensed

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15
Q

WHAT DO YOU CALL THE CELL WHEN ITS NUCLEUS IS VERY CONDENSED AND ITS PARACHROMATIN IS NO LONGER EVIDENT

A

PYKNOTIC

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16
Q

APPEARANCE OF THE HEAVY CLUMPING OF NUCLEAR CHROMATIN

A

RASPBERRY-LIKE APPEARANCE

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17
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND THE APPEARANCE OF SPECIFIC GRANULES

A

INDIRECT
Granules become less prominent and decrease in size

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18
Q

[RULES OF MATURATION]
RELATIONSHIP OF CELL MATURITY AND N:C RATIO

19
Q

STAIN USED IN PBS

A

MODIFIED ROMANOWSKY STAIN
WRIGHT OR WRIGHT-GIEMSA STAIN

20
Q

THE DISAPPEARANCE OF NUCLEOLI PRECEDES THE CESSATION OF WHAT CELLULAR PROCESS

A

PROTEIN SYNTHESIS

21
Q

COLOR TRANSITION OF CELLS AS THEY MATURE

A

BLUE
GRAY-BLUE
SALMON PINK

22
Q

WHAT IS THE PRINCIPLE OF BASOPHILIA IN CELLS

A

DUE TO ACIDIC COMPONENTS THAT ATTRACT BASIC STAINS

23
Q

BASIC STAIN USED

A

METHYLENE BLUE

24
Q

WHY DOES ACIDOPHILIA INCREASE AS CELLS MATURE

A

THE ACCUMULATION OF HEMOGLOBIN
Active protein production diminishes as cells mature
Hemoglobin synthesis begins to occur
The proteins and hemoglobin mix
Protein synthesis stops, ribosomes are no longer present, and only hemoglobin remains

25
Q

FOUR TYPES OF GRANULES

A

NEUTROPHILIC — TAN OR PURPLE
BASOPHILIC — BLUE
EOSINOPHILIC — DEEP ORANGE TO RED
AZUROPHILIC — PRIMARY GRANULES (??)

26
Q

[MATURATION POOLS]
PRECURSORS ARE CAPABLE OF CELL DIVISION

A

MITOTIC POOL

27
Q

[MATURATION POOLS]
CELLS NO LONGER DIVIDE

A

STORAGE POOL

28
Q

[MATURATION POOLS]
CELLS ARE READY FOR MATURATION

A

STORAGE POOL

29
Q

OTHER TERM FOR STORAGE POOL

A

MATURATION POOL

30
Q

[MATURATION POOLS]
CELLS ARE ACTIVELY DIVIDING

A

MITOTIC POOL

31
Q

[MATURATION POOL]
SEGMENTERS IN CIRCULATION

A

CIRCULATING POOL

32
Q

[MATURATION POOL]
CELLS FROM THIS POOL ARE STIMULATED TO MIGRATE TO THE TISSUES

A

CIRCULATING POOL

33
Q

[MATURATION POOL]
CELLS STAY AND REST

A

MARGINATING POOL

34
Q

[MATURATION POOL]
CELLS TEMPORARILY ADHERE TO THE EPITHELIAL CELLS

A

MARGINATING POOL
PAVEMENTING POOL

35
Q

CELL SURFACE LECTINS THAT ATTACH CELLS TO THE ENDOTHELIAL CELLS

36
Q

OTHER TERM FOR THE MARGINATING POOL

A

PAVEMENTING POOL

37
Q

[MATURATION POOL]
CELLS ARE ABLE TO PERFORM PHAGOCYTOSIS

A

TISSUE POOL

38
Q

[MATURATION POOL]
DIAPEDESIS OCCURS

A

TISSUE POOL

39
Q

WHAT IS DIAPEDESIS

A

THE EXIT OF CELLS FROM THE BLOOD VESSELS

40
Q

SUBSTANCES THAT INDUCE DIAPEDESIS

A

SELECTIN
INTEGRIN

41
Q

DIRECTION OF CELL MIGRATION DURING DIAPEDESIS

A

ZIGZAG MANNER

42
Q

DIRECTION OF CELL MIGRATION DURING CHEMOTAXIS

A

MOVEMENT IS STRAIGHT FORWARD

43
Q

CELLULAR MOVEMENT TOWARD OR AWAY FROM A CHEMICAL STIMULUS

A

CHEMOTAXIS

HEMATOLOGY (13 decks)

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