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HEMATOLOGY > [LEC] Granulopoiesis > Flashcards

[LEC] Granulopoiesis Flashcards

1
Q

PROGENITOR CELL OF GRANULOCYTES

A

CFU-G

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2
Q

WHAT GRANULOCYTE PRECURSORS ARE FOUND IN THE MITOTIC POOL

A

MYELOBLAST
PROMYLOCYTE
MYELOCYTE

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3
Q

WHAT GRANULOCYTE PRECURSOR CELLS ARE FOUND IN THE STORAGE POOL

A

METAMYELOCYTE
STAB/BAND CELL

NEUTROPHIL
EOSINOPHIL
BASOPHIL

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4
Q

MATURATION ORDER OF GRANULOPOIESIS

A

CFU-G
MYELOBLAST
PROMYELOCYTE
MYELOCYTE
METAMYELOCYTE
BAND/STAB CELL
NEUTROPHIL/EOSINOPHIL/BASOPHIL

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5
Q

GRANULOCYTE PRECURSORS THAT ARE CAPABLE OF DIVIDING

A

MYELOBLAST
PROMYELOCYTE
MYELOCYTE

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6
Q

GRANULOCYTES THAT ARE CAPABLE OF DIVIDING

A

MYELOBLAST
PROMYELOCYTE
MYELOCYTE

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7
Q

GRANULOCYTES INCAPABLE OF DIVIDING

A

METAMYELOCYTE
BAND/STAB CELL
NEUTROPHIL/EOSINOPHIL/BASOPHIL

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8
Q

GRANULES THAT ARE PRODUCED FIRST BUT USED LAST

A

PRIMARY OR AZUROPHILIC GRANULES

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9
Q

GRANULES THAT ARE PRODUCED LAST BUT USED FIRST

A

TERTIARY GRANULES

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10
Q

PRECURSOR CELL THAT PRODUCES PRIMARY GRANULES

A

PROMYELOCYTE

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11
Q

PRECURSOR CELL THAT PRODUCES SECONDARY GRANULES

A

MYELOCYTE

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12
Q

PRECURSOR CELL THAT PRODUCES TERTIARY GRANULES

A

METAMYELOCYTE

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13
Q

PRESENCE OF GRANULES IN THE MYELOBLAST

A

NONE

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14
Q

COLOR OF THE MYELOBLAST’S CYTOPLASM

A

PALE OR CLEAR BLUE

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15
Q

DIAMETER OF THE MYELOBLAST

A

15 UM

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16
Q

WHAT NUCLEAR PRODUCT DOES THE PROMYELOCYTE MAKE

A

PRIMARY OR AZUROPHILIC GRANULES

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17
Q

CHROMATIN BEGINS TO CLUMP IN THIS PRECURSOR CELL

A

PROMYELOCYTE

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18
Q

WHAT NUCLEAR PRODUCT DOES THE MYELOCYTE MAKE

A

SECONDARY OR SPECIFIC GRANULES

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19
Q

PRECURSOR CELL WITH THE D SHAPED NUCLEUS

A

MYELOCYTE

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20
Q

SHAPE OF THE MYELOCYTE’S NUCLEUS

A

D SHAPED

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21
Q

COLOR OF THE MYELOCYTE’S CYTOPLASM

A

PINK

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22
Q

SEEMINGLY HOURGLASS SHAPE

A

MYELOCYTE

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23
Q

LAST CELL CAPABLE OF CELL DIVISION

A

MYELOCYTE

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24
Q

DAWN OF NEUTROPHILIA
-Identify the cell and state the cause

A

MYELOCYTE
Transition of cytoplasm’s color from blue to pink
Protein production reduces
Basophilia decreases

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25
Q

WHAT NUCLEAR PRODUCT DOES THE METAMYELOCYTE MAKE

A

TERTIARY GRANULES

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26
Q

SHAPE OF THE METAMYELOCYTE NUCLEUS

A

KIDNEY SHPE
Indented nucleus
Not more than half of the nucleus

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27
Q

CELL WITH THE KIDNEY SHAPED NUCLEUS

A

METAMYELOCYTE

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28
Q

CELL WITH THE FIRST NUCLEAR CHANGE

A

METAMYELOCYTE

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29
Q

INDENTATION OF THE NUCLEUS IS MORE THAN HALF OF IT IN THIS CELL

A

STAB OR BAND CELL

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30
Q

HAS A C SHAPED NUCLEUS

A

BAND OR STAB CELL

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31
Q

IMMATURE GRANULOCYTE ALLOWED TO ENTER PERIPHERAL CIRCULATION

A

STAB OR BAND CELL

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32
Q

[TRUE OR FALSE]
THE PRESENCE OF THE BAND CELL IN CIRCULATION IS OF CLINICAL SIGNIFICANCE

A

FALSE

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33
Q

RATIO OF SEGMENTERS TO PRECURSORS

A

1:16
1 SEGEMENTED @ PC
16 PRECURSORS @ BM

34
Q

WHERE ARE SEGMENTERS FOUND IN

A

PERIPHERAL CIRCULATION

35
Q

WHERE ARE PRECURSORS FOUND IN

A

BONE MARROW

36
Q

PERIOD OF TIME IN BETWEEN TRANSITIONS FROM

MYELOCYTE TO SEGMENTER TO STORAGE POOL

A

MYELOCYTE -14 DAYS- SEGMENTER - 6-7 DAYS- STORAGE POOL

37
Q

DESCRIBE THE TRAVEL MECHANISM OF NEUTROPHILS

A

NEUTROPHILS ATTACH TO THE ENDOTHELIUM AND SQUEEZE OUT VIA DIAPEDESIS

CHEMOTAXINS HELP THEM TRAVEL DIRECTLY TO THE SITE OF CELL DESTRUCTION

38
Q

ENUMERATE AND DESCRIBE THE PHAGOCYTOSIS PROCESS

A

RECOGNITION and ATTACHMENT
Determine self from non self

INGESTION
Formation of the phagosome

KILLING AND DESTRUCTION

39
Q

ENUMERATE THE TWO KINDS OF NEUTROPHIL KILLING MECHANISMS

A

O2 DEPENDENT
Granules release superoxides

O2 INDEPENDENT
Changes in pH occur
From alkaline to neutral

40
Q

KILLING MECHANISM THAT USESS SUPEROXIDES RELEASED BY GRANULES

A

O2 DEPENDENT

41
Q

KILLING MECHANISM THAT CHANGES PH

A

O2 INDEPENDENT

42
Q

THE FUSION OF A NEUTROPHIL AND AN INGESTED BODY RESULTS IN WHAT

A

PHAGOSOME

43
Q

ORDER OF GRANULE USAGE

A

TERTIARY — SECONDARY — PRIMARY

44
Q

PROGENITOR CELL OF EOSINPHILS

A

CFU-EO

45
Q

COLOR OF THE INITIAL GRANULES OF THE EOSINOPHIL

A

OLIVE GREEN

46
Q

COLOR OF THE MATURE GRANULES OF THE EOSINOPHIL

A

DEEP ORANGE TO RED

47
Q

CHARACTERISTIC APPEARANCE OF THE EOSINOPHIL NUCLEUS

A

CLASSIC HEADPHONE SHAPE

48
Q

CORE PROTEINS OF THE EOSINOPHIL

A

MAJOR BASIC PROTEIN

49
Q

PH OF THE MBP

A

ALKALINE

50
Q

STRAINING PROPERTY OF THE MBP

A

DEEP ORANGE TO RED

51
Q

GENERAL FUNCTION OF THE EOSINOPHIL

A

DAMPEN OR WEAKEN THE IMMUNE RESPONSE
Counters the enhancing effect of basophils

52
Q

AN INCREASE OF EOSINOPHILS CAN BE SEEN IN WHAT CLINICAL CONDITIONS

A

ACTIVE PARASITISM

53
Q

FOUR MAIN FUNCTIONS OF EOSINOPHILS

A

DEGRANULATION
Directly kill the organism
Release granules
Mediate basophil function

REGULATION OF IMMUNE RESPONSE
Work with APCs

INDICATORS OF PARASITIC INFECTIONS
Major basic proteins battle helminths

HALLMARK OF ALLERGIC REACTIONS

54
Q

PREFERRED SPECIMEN FOR THE DETECTION OF CHARCOT LEYDEN CRYSTALS

A

SPUTUM

55
Q

HALLMARK OF RESPIRATORY CONDITIONS

A

CHARCOT LEYDEN CRYSTALS

56
Q

CYTOKINE THAT HELPS REPAIR DAMAGED TISSUE

A

FIBROGENIC DERIVED GROWTH FACTOR

57
Q

PROGENITOR CELL OF BASOPHILS

A

CFU-BASO

58
Q

GROWTH FACTOR THAT CONVERTS EOSINOPHILS TO BASOPHILS

A

TGF-Beta
Transforming Growth Factor - Beta

59
Q

CYTOKINE THAT EXERT A POSITIVE INFLUENCE ON BASOPHILS

A

IL-3
IL-5

60
Q

SOLUBLE PROTEINS THAT HAVE DIRECT AND INDIRECT EFFECTS OF HEMATOPOIETIC CELLS

A

CYTOKINES

61
Q

CELL WITH GRANULES THAT OBSCURE ALMOST THE WHOLE CELL

A

BASOPHILS

62
Q

GRANULES THAT FORM IN THE METAMYELOCYTE STAGE

A

METACHROMATIC GRANULES
Making it a TERTIARY granules

63
Q

AZUROPHILIC GRANULES OF THE BASOPHILS

A

METACHROMATIC GRANULES

64
Q

GRANULES THAT CHANGE COLORS AT DIFFERENT LIGHT INTENSITIES

A

METACHROMATIC

65
Q

SUBSTANCE BASOPHILS RELEASE TO INCREASE ALLERGIC REACTIONS

A

HISTAMINE

66
Q

SUBSTANCE BASOPHILS RELEASE TO PREVENT BLOOD FROM CLOTTING

A

HEPARIN

67
Q

FUNCTIONS OF THE BASOPHIL

A

RESPOND TO ADRENAL CORTICOSTEROIDS
IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS
RELEASE CYTOKINES
INDUCE THE SYNTHESIS OF IGE
ANGIOGENESIS
CONTROL HELMINTH INFECTIONS

68
Q

WHAT CELL IS THE MOST EFFICIENT AT COMBATING HELMINTH INFECTIONS

A

EOSINOPHILS

69
Q

REPAIRING OR FORMATION OF BLOOD VESSELS IS TERMED AS

A

ANGIOGENESIS

70
Q

IMMUNOGLOBULIN THAT INCREASES DUE TO BASOPHILS

A

IgE

71
Q

[FUNCTION OF WHAT CELL]
PHAGOCYTOSIS

A

NEUTROPHIL

72
Q

[FUNCTION OF WHAT CELL]
REGULATION OF THE IMMUNE RESPONSE WITH APCs

A

EOSINOPHILS

73
Q

[FUNCTION OF WHAT CELL]
INDICATOR OF PARASITIC INFECTIONS

A

EOSINOPHILS

74
Q

[FUNCTION OF WHAT CELL]
HALLMARK OF ALLERGIC REACTIONS

A

EOSINOPHILS

75
Q

[FUNCTION OF WHAT CELL]
RESPOND TO ADRENAL CORTICOSTEROIDS

A

BASOPHILS

76
Q

[FUNCTION OF WHAT CELL]
IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS

A

BASOPHILS

77
Q

[FUNCTION OF WHAT CELL]
RELEASE OF CYTOKINES

A

BASOPHILS

78
Q

[FUNCTION OF WHAT CELL]
INDUCES THE SYNTHESIS OF IgE

A

BASOPHILS

79
Q

[FUNCTION OF WHAT CELL]
ANGIOGENESIS

A

BASOPHILS

80
Q

[FUNCTION OF WHAT CELL]
CONTROL HELMINTH INFECTIONS

A

MAINLY EOSINOPHILS
BASOPHILS

81
Q

CELL THAT RESEMBLES BASOPHILS

A

MAST CELLS

HEMATOLOGY (13 decks)

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