lec 5

Question 1

Atheromatous plaques are composed of

Answer 1

lipid cores (mainly cholesterol and cholesterol esters, with necrotic debris) covered by fibrous caps

Question 2

CRP levels predict the risk for

Answer 2

myocardial infarction,
stroke,
peripheral arterial disease,
and sudden cardiac death

Question 3

Metabolic syndrome entity is characterized

Answer 3

by insulin resistance, 
hypertension,
 dyslipidemia 
 hypercoagulability, 
 pro-inflammatory state, which

Question 4

The two most important causes of endothelial dysfunction are

Answer 4

are hemodynamic disturbances and hypercholesterolemia.

Question 5

common site of Plaques

Answer 5

at ostia of exiting vessels, at branch points, and along the posterior wall of the abdominal aorta, where there is turbulent blood flow.

Question 6

Common lipoprotein abnormalities

Answer 6

(1) increased LDL cholesterol levels,
(2) decreased HDL cholesterol levels, &
(3) increased levels of lipoprotein(a).

Question 7

, lipoproteins accumulate within the intima to generate two pathogenic derivatives

Answer 7

, oxidized LDL

cholesterol crystals.