LEC 4 - Larva Migrans Flashcards

(66 cards)

1
Q

Denotes that if a person is infected with the larva, the larva will start crawling in the tissues of the infected host, they migrate sa body ng infected host

A

LARVA MIGRANS

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2
Q

skin (epidermis)

A

Cutaneous Larva Migrans

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3
Q

visceral organs (soft internal organs)

A

Visceral Larva Migrans

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4
Q

a type of VLM, another effect of VLM, parasite migrated in the eyes of the host (periorbital region)

A

Ocular Larva Migrans

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5
Q

Site of Infections

A

Site of Infection
* Heart
* Lungs
* Digestive organs
* Reproductive organs
* Circulatory organs
* Excretory organs

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6
Q

not a typical part of the life cycle of the parasite, infected because the host was exposed to the parasite, the larvae will no longer developed to become adult

A

Accidental Host

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7
Q

also known as Toxocariasis, caused by Toxocara spp

A

Visceral Larva Migrans

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8
Q

if the periorbital region is involved

A

Ocular Larva Migrans

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9
Q

also known as creeping eruption or
ground itch

A

Cutaneous Larva Migrans

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10
Q

Etiologic Agent of CLM:

A
  • Anyclostoma braziliense (cat hookworm)
  • Anyclostoma caninum (dog hookworm)
  • Strongyloides stercoralis – Larva Currens/Racing Larva
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11
Q

Rate of migration

A

5-15 cm/hr

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12
Q

associated with S.stercoralis, “Vietnam”

A

Cochin – China Diarrhea

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13
Q

Infective Stage of CLM

A

Filariform Larva

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14
Q

MOT of CLM

A

Skin penetration of larvae from soil

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15
Q

(CLM)
Etiology Most Common na CAT & DOG HOOKWORMS

A

Ancylostoma Braziliense

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16
Q

Etiology Less Common(CLM) - Dog Hookworms

A
  • A.tubaeforme,
  • A. caninum,
  • A. ceylanicum,
  • Uncinaria stenocephala
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17
Q

CLM Treatment

A

Self-limiting (larvae die in weeks to months)
Medication to relieve or alleviate pain and symptoms, dili contagious tho

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18
Q

VLM MOT

A

Ingestion if embryonated eggs from soil; ingestion of encysted larvae from animal organs

Can be harbored by ducks or rabbits (paratenic host)

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19
Q

(CLM)
Etiology Less Common - Animal strongyloidiasis

A
  • S. myopotami
  • S. papillosus
  • S. westeri
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20
Q

(CLM)
Etiology Less Common - Cat, dog, pig roundworms

A
  • Gnasthostoma spp.
  • Gnathostoma spinigerum
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21
Q

(CLM)
Etiology Less Common - Cat, dog, poultry, & rodent whipworms

A

Capillaria spp.

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22
Q

(CLM)
Etiology Less Common - Cattle hookworm

A

Bunostomum phlebotomum

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23
Q

(CLM)
Etiology Less Common - Human hookworms

A

Ancylostoma duodenale
Necator americanus (ground itch)

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24
Q

(CLM)
Etiology Less Common - Human Strongyloidiasis

A

S. stercoralis (larva currens)

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25
Infective Stage of VLM
Filariform Larva
26
VLM Etiology MOST COMMON - Cat and Dog Nematodes
Toxocara canis Toxocara catis
27
VLM Etiology LESS COMMON - Dog/Cat
* Toxoscaris leonine * Toxocara vitulorum * Toxocara pleropodis
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VLM Etiology LESS COMMON - Racoon
Baylisascaris procyonis
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VLM Etiology LESS COMMON - Pig
Ascaris suum
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VLM Etiology LESS COMMON - Rare
* Angiostrongylus cantonensis * Angiostrongylus costaricensis * Anisakis spp. * Capillaria hepatica * Dirofilaria immitis * Gnasthostoma spinigerum * Gongylonema spp. * Lagochilascaris * Pseudoterranova spp.
31
– raw salt water fish, causes anisakiasis (kapatid ni Anisakis)
Pseudoterranova spp.
32
VLM Treatment
Need treatment due to the severity of symptoms
33
According to Panikers, The larvae produce ____________, which develop into ____________ in the epidermis. With the movements of the larva in the skin, the lesion also shifts, hence the name ‘creeping eruption. Scratching may lead to secondary bacterial infection
itching papules; serpiginous tunnels
34
Strongyloides rare sa feces, because it is
ovoviviparous Rhabditiform larva
35
To identify hookworm from Strongyloides: (Fecal Cultures)
1.Harada Mori 2. Sand & Charcoal/Baermann 3. Koga Agar Plate Culture
36
abnormal tracks below the skin surface in the feet (30%) o Stinging sensation upon penetration o Larva starts migrating 1 week to several months after penetration o Larvae forms tract 1-2 cm. beyond
CREEPING ERUPTIONS
37
o 2-4mm wide o Erythematous (reddish), elevated, vesicular, itchy : o Erratic Pattern (snake-line/serpiginous means wavy) o Progresses 2mm to 2cm/day
MIGRATORY TRACT/ TRAIL
38
Anyone in contact with sand/soil in warm, moist, shady areas: o Sunbathers o Fishermen o Hunters o Gardeners o Constriction workers o Children plating in sandboxes, beach
AT RISK GROUPS
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Resolve with/without treatment, no long-term complications Pruritic lesions → scratching → skin blisters wound open to secondary bacterial infection
Morbidity (self-limiting)
40
Mortality of Cutaneous Larva Currens
None
41
Diagnosis of CLM
o Physical examination & medical history o Skin biopsy not necessary o Peripheral eosinophilia o Coherence tomography (imaging test to view larvae & remove them)
42
REMEMBER CLASS!!!
Eosinophilia – for parasitic infection Basophilia – viral infections Neutrophil – bacterial infections
43
TREATMENT of CLM - Without drugs
Self-heal
44
TREATMENT of CLM - With anti-helminthic drugs
- Albendazole (oral) - Mebendazole (oral) - Thiabendazole (topical) - Ivermectin (oral)
45
TREATMENT of CLM - Supportive Therapy
- Antihistamines (relieve itching) - topical corticosteroids (relieve inflammation) - antibiotics (secondary infections)
46
TREATMENT of CLM - Surgical care
- cryosurgery (painful, requires multiple treatment) - liquid nitrogen - ethyl chloride spray - carbon dioxide slush
47
CLM PREVENTION
o Avoid direct contact with contaminated soil: wear shoes on the beach, lay towels behind your backs on the sand, garden gloves o Prohibit dogs & cats on beaches o Deworm pets regularly o Cover sandboxes when not in use to avoid animals defecating
48
* Disease affecting younger children (<5 years old) * Symptoms due to antigens secreted by the migrating larvae
Visceral Larva Migrans
49
* Larvae migrate to lungs, liver, eyes, brain, muscles (visceral organs) * Majority asymptomatic to gradual symptoms
Visceral Larva Migrans
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* Symptoms of allergy & inflammatory response:
- Wheezing - Breathlessness - asthma-like - cough - itchy skin - fever - headache - generalized weakness - tiredness - muscle pain - seizures
51
Cardinal Signs of Inflammation Rubor
Redness
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Cardinal Signs of Inflammation Calor
Heat
53
Cardinal Signs of Inflammation Tumor
Swelling
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Cardinal Signs of Inflammation Dolor
Pain
55
Cardinal Signs of Inflammation Funtio laesa
loss of function
56
*When migrating larval nematode invade the eye of the host * More often in older children (5-10 y/0) & young adults compared to VLM (more often in young children 4-5 y/o) * Symptoms of VLM may or may not be present
OCULAR LARVA MIGRANS
57
Eye involvement often leads to unilateral vision loss, cross eye called
strabismus
58
Etiologic agents of OLM
- Toxocara canis & T. cati (most common) → ocular Toxocariasis - Baylisascaris procyonis – racoon - Ancylostoma spp. - Gnasthostoma spinigerum – swine
59
DIAGNOSIS OF OLM - Serology
ELISA (Enzyme Link Immunosorbent Assay) using Toxocara excretory-secretory antigens - Study of antigen and antibody - Antibodies against Toxocara spp. (+ na-exposed ka sa Toxocara)
60
DIAGNOSIS OF OLM - Peripheral blood count
High eosinophilia (may be absent on OLM) - CBC count – not definitive, clue lang - High eosinophil count – helminthiasis
61
DIAGNOSIS OF OLM - imaging
chest X-ray
62
DIAGNOSIS OF OLM - Histology
Encysted larvae in liver, lungs, brain, eyes
63
TREATMENT AND PREVENTION OF OLM - * Anti-helminthic drugs:
- Albendazole - Mebendazole - Diethylcarbamazine (DEC)
64
TREATMENT AND PREVENTION OF OLM - Supportive Therapy
Steroids during wheezing, inflamed tissues - Removal of granulomas in the eyes
65
TREATMENT AND PREVENTION OF OLM - Prevention
- Careful child supervision - Wash hands before eating - Wash hands after playing with pets - Cover sandboxes - Regular deworming of pets - Cook liver & other organ meats well before eating
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calcification or scarring that can lead to blindness
granulomas