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PCL201 > Lec 20: street drugs > Flashcards

Lec 20: street drugs Flashcards

1
Q

how to study effects of brain drugs``

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2
Q

commonly misused substances

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3
Q

differences and similarities between misused substances

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4
Q

describe the dpoamine reward pathway general

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5
Q

how does the reward system work when unstimulated? what is gaba doing? what is the role of gaba? whats happening to the da cell?

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6
Q

what happens to da when gaba gets turned off? what feelings does this lead to? examples ?

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7
Q

which drugs are most likely for dependence? withdrawal? tolerence? reinforcement? intoxication?

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8
Q

how does thc work (ie where does it bind)? where?

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9
Q

what receptors does thc activate? what does this do?

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10
Q

what does thc mimic? what does this do?

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11
Q

whats the onset time for thc? how can yous shorten it?

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12
Q

explain bioavailibility of thc? solubility? excretion? active ingredient? half life?

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13
Q

types of opiods?

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14
Q

what are opioid action mechs?

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15
Q

how are opioids misused (mech)

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16
Q

whats the opioid reward pathway? contrast with typical

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17
Q

what does opioids do to gpc receptors? what does this do?

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18
Q

what kind of isomer is morphine found in?

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19
Q

physio effects of morphine?

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20
Q

metabolism of morphine? peak conc levels? ionization? metabolite?

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21
Q

what are the derivatives of opioids?

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22
Q

t/f: route of admin isnt important to addiction and misuse

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23
Q

what kind of opioid is heroin? compare potency with morphine?

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24
Q

what does heroin mimic? what does this do?

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25
Q

compare pharmacokinetics heroin vs morphine

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26
Q

effects of heroin? what does it do to reward pathway?

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27
Q

withdrawl and therapy of heroin?

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28
Q

what are two types of synthetic opioids?

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29
Q

contrats oxycontin and oxyneo

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30
Q

fentanyl vs morphine potency? admin route?

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31
Q

carfent vs fent vs morphine?

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32
Q

what are benzos used for?

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33
Q

sims and difs of benzos

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34
Q

why are benzos most appropriated? how are they used in speedballs?how are they used with other depressants?

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35
Q

what are the physiological effects of benzos

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36
Q

how does tolerance develop in benzos

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37
Q

withdrawal symptoms

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38
Q

ketamine is a chem substituent of

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39
Q

explain mechanism of ketamine

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40
Q

how is ketamoine metabolised

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41
Q

onset and duration of ketamine? major use?

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42
Q

effect of ketamine on cardiovasc? cerebral blood flow? intercranial pressure?

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43
Q

contrast low dose vs high dose effects of ketamine

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44
Q

ketamine effects on dopamine>

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45
Q

as dose escalates what happens to tolerance (ketamine)

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46
Q

how is ketamine admin? what happens with long term use? one way ketamine is used?

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47
Q

what are examples of psychostimulants? what do they do?

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48
Q

what form of amphetomines are in cns? what so they do? what does ne hyperactivity lead to?

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49
Q

what does da hyperactivity lead to?

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50
Q

halflife and speed of amphetomines? met? peripheral action?

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51
Q

toxic effects of amphetamines?

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52
Q

meth structure is similar to? mechanism? physiological effects? half life, onset, and duration? metabolism.

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53
Q

drug category of cocaine? mech of action?

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54
Q

how does cocaine get misused?

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55
Q

cocaine vs opioids: withdrawal?

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56
Q

which plant does cocaine come from>

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57
Q

pk of intranasal cocaine (entrance to cns? onset? duration? half life?) metabolism? byproducts?

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58
Q

secondary effects of cocaine? acute effects?

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59
Q

what happens in high doses of cocaine? overdoses? chronic uses?

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60
Q

describe da pathway of cocaine? describe da depletion?

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61
Q

what is crack? effct on absorption? why is it more cardio toxic?

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62
Q

what are adulterants?

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63
Q

what is levimasole? consequences?

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64
Q

what is xylazine? consequences?

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65
Q

how can u reduce harm of street drugs?

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66
Q

what is ecstasy? what type of drug?

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67
Q

effects of ecstasy? receptor? mechanism?

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68
Q

bioavailibility and halflife of ecstasy?

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PCL201 (19 decks)

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