Lec 20: street drugs

Question 1

how to study effects of brain drugs``

Question 2

commonly misused substances

Question 3

differences and similarities between misused substances

Question 4

describe the dpoamine reward pathway general

Question 5

how does the reward system work when unstimulated? what is gaba doing? what is the role of gaba? whats happening to the da cell?

Question 6

what happens to da when gaba gets turned off? what feelings does this lead to? examples ?

Question 7

which drugs are most likely for dependence? withdrawal? tolerence? reinforcement? intoxication?

Question 8

how does thc work (ie where does it bind)? where?

Question 9

what receptors does thc activate? what does this do?

Question 10

what does thc mimic? what does this do?

Question 11

whats the onset time for thc? how can yous shorten it?

Question 12

explain bioavailibility of thc? solubility? excretion? active ingredient? half life?

Question 13

types of opiods?

Question 14

what are opioid action mechs?

Question 15

how are opioids misused (mech)

Question 16

whats the opioid reward pathway? contrast with typical

Question 17

what does opioids do to gpc receptors? what does this do?

Question 18

what kind of isomer is morphine found in?

Question 19

physio effects of morphine?

Question 20

metabolism of morphine? peak conc levels? ionization? metabolite?

Question 21

what are the derivatives of opioids?

Question 22

t/f: route of admin isnt important to addiction and misuse

Question 23

what kind of opioid is heroin? compare potency with morphine?

Question 24

what does heroin mimic? what does this do?

Question 25

compare pharmacokinetics heroin vs morphine

Question 26

effects of heroin? what does it do to reward pathway?

Question 27

withdrawl and therapy of heroin?

Question 28

what are two types of synthetic opioids?

Question 29

contrats oxycontin and oxyneo

Question 30

fentanyl vs morphine potency? admin route?

Question 31

carfent vs fent vs morphine?

Question 32

what are benzos used for?

Question 33

sims and difs of benzos

Question 34

why are benzos most appropriated? how are they used in speedballs?how are they used with other depressants?

Question 35

what are the physiological effects of benzos

Question 36

how does tolerance develop in benzos

Question 37

withdrawal symptoms

Question 38

ketamine is a chem substituent of

Question 39

explain mechanism of ketamine

Question 40

how is ketamoine metabolised

Question 41

onset and duration of ketamine? major use?

Question 42

effect of ketamine on cardiovasc? cerebral blood flow? intercranial pressure?

Question 43

contrast low dose vs high dose effects of ketamine

Question 44

ketamine effects on dopamine>

Question 45

as dose escalates what happens to tolerance (ketamine)

Question 46

how is ketamine admin? what happens with long term use? one way ketamine is used?

Question 47

what are examples of psychostimulants? what do they do?

Question 48

what form of amphetomines are in cns? what so they do? what does ne hyperactivity lead to?

Question 49

what does da hyperactivity lead to?

Question 50

halflife and speed of amphetomines? met? peripheral action?

Question 51

toxic effects of amphetamines?

Question 52

meth structure is similar to? mechanism? physiological effects? half life, onset, and duration? metabolism.

Question 53

drug category of cocaine? mech of action?

Question 54

how does cocaine get misused?

Question 55

cocaine vs opioids: withdrawal?

Question 56

which plant does cocaine come from>

Question 57

pk of intranasal cocaine (entrance to cns? onset? duration? half life?) metabolism? byproducts?

Question 58

secondary effects of cocaine? acute effects?

Question 59

what happens in high doses of cocaine? overdoses? chronic uses?

Question 60

describe da pathway of cocaine? describe da depletion?

Question 61

what is crack? effct on absorption? why is it more cardio toxic?

Question 62

what are adulterants?

Question 63

what is levimasole? consequences?

Question 64

what is xylazine? consequences?

Question 65

how can u reduce harm of street drugs?

Question 66

what is ecstasy? what type of drug?

Question 67

effects of ecstasy? receptor? mechanism?

Question 68

bioavailibility and halflife of ecstasy?