lec 2: pharmkin Flashcards
1
Q
what is pharmacokin
A
2
Q
what is adme? each part?
A
3
Q
pupose of pk
A
4
Q
process of finding pk
A
5
Q
what is absorption? how does admin route impact?
A
6
Q
what is dist? what does it depend on?
A
7
Q
what is metabolism and excretion?
A
8
Q
what is pharmacodynamics
A
9
Q
what is the lock and key inetraction
A
10
Q
describe most drug ints
A
11
Q
qualities of irreversible drug ints?
A
12
Q
agonist action
A
13
Q
what are receptors? ligands? effector molecules?
A
14
Q
adenylyl cyclase pathway
A
15
Q
effect of inc camp?
A
16
Q
qualities of drug target ints
A
17
Q
what is intrinsic activity vs affinity
A
18
Q
nature of drug target int
A
19
Q
how to measure drug ints w dose resp curve? typical responses?
A
20
Q
efficacy vs potency
A
21
Q
is high potency always betweet
A
22
Q
lethal dose respo curves: what they show
A
23
Q
therapeutic index
A
24
Q
drugs are classified as…
A
25
what are agonists
26
what are full agonists
27
what is salbutamol? type of drug? describe role
28
what are partial agonists?
29
what is pindolol? desribe role?
30
what are positive allosteric mods?
31
how do pos all mods affect dose resp curve
32
what is diazepam? effect?
33
what are phar vs chem vs physio antagonists/blockers? examples?
34
contrast antagonist vs blocker and inhibitors
35
what are antagonists
36
how do antag affect dose resp curve
37
what are competitive antagswhat is propanolo? explain role?
38
what are non comp antags?
39
what are neg allo mods? effect on
dr curve?
40
what is bcarboline? role?
41
what are irrev antags? effect on dr curve?
42
other mechanisms of drug action?
43
characteristics of bio membranes
44
what affects how drugs permeate
45
desrcibe molec size variability and how they cross membranes
46
describe solubility variation and what affects it
47
describe hydrophillicity significance for drugs
48
describe lipphillicity significance? where will more of these drugs end up
49
what is the role of func groups in drugs
50
contrast polar and no problem groups
51
WHAT ARE AMPHPATHIC MOLECULUES
52
WHAT IS THE PARTITION COEFFICIENT AND WHAT DOES IT MEASURE
53
HOW DOES SOLUBILITY INDICATE PERMEABILITY
54
WHAT IS POW AT EQ
55
BALANCE WRT HYDROPHILLICITY AND LIPOPHILLICITY: IMPORTANCE?
56
FICKS LAW OF DIFFUSION
57
DRUGS WITH HIGH LIPID SOLUBILITY: BHVR AT CELL MEMBRANES
58
DESCRIBE WHY IONIZATION IS IMPORTANT FOR DRUGS
59
WHICH TYPE OF DRUGS WILL CROSS MEMBRANES
60
WHAT DETERMINES DRUG IONIZATION? WHEN ARE ACIDIC DRUGS IONIZED? WHEN ARE BASIC DRUGS IONIZED
61
WHAT HAPPENS TO ACIDIC DRUGS AT HIGH PH? LOW PH? WHEN ARE THEY CHARGED?
62
WHAT HAPPENS TO BASIC DRUGS AT HIGH PH? LOW PH? WHEN ARE THEY CHARGED?
63
COMPARTMENTS WITH LOW PH: WHAT DRUGS ARE IONIZED?
64
COMPARETMENTS WITH HIGH PH: WHAT DRUGS ARE IONIZED?
65
HOW TO USE HENDERSON HASSELBACH TO FIND OUT HOW MUCH DRUG IS IONIZED AT A CERTAIN PH
66
WHAT IS PKA? WHAT DOES IT TELL US? WHAT DOES IT NOT TELL US?
67
WHAT DOES IONIZATION DTERMINE?
68
PH IN DIFFERENT COMPARTMENTS? WHAT DOES THAT MEAN FOR DRUGS>
69
WHAT IS DRUG TRAPPING? HOW DOES IT HAPPEN?
70
DESCRIBE HOW YOU COULD ENHANCE RENAL SECRETION
71
WHAT IS RATIONAL DRUG DESIGN?
