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PCL201 > lec 2: pharmkin > Flashcards

lec 2: pharmkin Flashcards

1
Q

what is pharmacokin

A
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2
Q

what is adme? each part?

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3
Q

pupose of pk

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4
Q

process of finding pk

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5
Q

what is absorption? how does admin route impact?

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6
Q

what is dist? what does it depend on?

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7
Q

what is metabolism and excretion?

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8
Q

what is pharmacodynamics

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9
Q

what is the lock and key inetraction

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10
Q

describe most drug ints

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11
Q

qualities of irreversible drug ints?

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12
Q

agonist action

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13
Q

what are receptors? ligands? effector molecules?

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14
Q

adenylyl cyclase pathway

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15
Q

effect of inc camp?

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16
Q

qualities of drug target ints

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17
Q

what is intrinsic activity vs affinity

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18
Q

nature of drug target int

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19
Q

how to measure drug ints w dose resp curve? typical responses?

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20
Q

efficacy vs potency

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21
Q

is high potency always betweet

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22
Q

lethal dose respo curves: what they show

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23
Q

therapeutic index

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24
Q

drugs are classified as…

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25
Q

what are agonists

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26
Q

what are full agonists

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27
Q

what is salbutamol? type of drug? describe role

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28
Q

what are partial agonists?

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29
Q

what is pindolol? desribe role?

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30
Q

what are positive allosteric mods?

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31
Q

how do pos all mods affect dose resp curve

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32
Q

what is diazepam? effect?

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33
Q

what are phar vs chem vs physio antagonists/blockers? examples?

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34
Q

contrast antagonist vs blocker and inhibitors

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35
Q

what are antagonists

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36
Q

how do antag affect dose resp curve

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37
Q

what are competitive antagswhat is propanolo? explain role?

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38
Q

what are non comp antags?

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39
Q

what are neg allo mods? effect on
dr curve?

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40
Q

what is bcarboline? role?

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41
Q

what are irrev antags? effect on dr curve?

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42
Q

other mechanisms of drug action?

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43
Q

characteristics of bio membranes

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44
Q

what affects how drugs permeate

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45
Q

desrcibe molec size variability and how they cross membranes

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46
Q

describe solubility variation and what affects it

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47
Q

describe hydrophillicity significance for drugs

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48
Q

describe lipphillicity significance? where will more of these drugs end up

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49
Q

what is the role of func groups in drugs

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50
Q

contrast polar and no problem groups

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51
Q

WHAT ARE AMPHPATHIC MOLECULUES

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52
Q

WHAT IS THE PARTITION COEFFICIENT AND WHAT DOES IT MEASURE

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53
Q

HOW DOES SOLUBILITY INDICATE PERMEABILITY

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54
Q

WHAT IS POW AT EQ

A
55
Q

BALANCE WRT HYDROPHILLICITY AND LIPOPHILLICITY: IMPORTANCE?

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56
Q

FICKS LAW OF DIFFUSION

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57
Q

DRUGS WITH HIGH LIPID SOLUBILITY: BHVR AT CELL MEMBRANES

A
58
Q

DESCRIBE WHY IONIZATION IS IMPORTANT FOR DRUGS

A
59
Q

WHICH TYPE OF DRUGS WILL CROSS MEMBRANES

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60
Q

WHAT DETERMINES DRUG IONIZATION? WHEN ARE ACIDIC DRUGS IONIZED? WHEN ARE BASIC DRUGS IONIZED

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61
Q

WHAT HAPPENS TO ACIDIC DRUGS AT HIGH PH? LOW PH? WHEN ARE THEY CHARGED?

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62
Q

WHAT HAPPENS TO BASIC DRUGS AT HIGH PH? LOW PH? WHEN ARE THEY CHARGED?

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63
Q

COMPARTMENTS WITH LOW PH: WHAT DRUGS ARE IONIZED?

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64
Q

COMPARETMENTS WITH HIGH PH: WHAT DRUGS ARE IONIZED?

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65
Q

HOW TO USE HENDERSON HASSELBACH TO FIND OUT HOW MUCH DRUG IS IONIZED AT A CERTAIN PH

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66
Q

WHAT IS PKA? WHAT DOES IT TELL US? WHAT DOES IT NOT TELL US?

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67
Q

WHAT DOES IONIZATION DTERMINE?

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68
Q

PH IN DIFFERENT COMPARTMENTS? WHAT DOES THAT MEAN FOR DRUGS>

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69
Q

WHAT IS DRUG TRAPPING? HOW DOES IT HAPPEN?

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70
Q

DESCRIBE HOW YOU COULD ENHANCE RENAL SECRETION

A
71
Q

WHAT IS RATIONAL DRUG DESIGN?

A

PCL201 (19 decks)

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