Lec 20 Reproductive Pharm Flashcards
1
Q
What are the 3 major estrogens produced by women?
A
- estradiol
- estrone
- estriol
2
Q
Where is estradiol secreted from?
A
from ovary
3
Q
Where are estrone/estriol secreted from?
A
mostly formed in liver from estradiol or in peripheral tissue from other androgens
4
Q
Where is progesterone synthesized?
A
by ovary [corpus luteum], testis, and adrenal cortex from circulating cholesterol
5
Q
Where is testosterone produced?
A
95% by leydig cells
5% in adrenal
6
Q
What causes increase in SHBG?
A
- estrogen
- thyroid hormone
- cirrhosis
7
Q
What causes decrease in SHBG?
A
- androgens
- growth hormone
- obesity
8
Q
How does testosterone circulation?
A
65% bound to sex hormone binding globulin
2% free
the rest bound to albumin
9
Q
What causes conversion of testosterone to estradiol?
A
P450 aromatase
10
Q
What causes conversion of testosterone to 5HT?
A
5 alpha reductase
