Lec 20 Oncology Intro

Question 1

What is median age of diagnosis new malignancy?

Answer 1

66

Question 2

What are the top 2 leading causes of death in the US in order?

Answer 2

1. heart disease

2. malignancy

Question 3

What are the top 3 most common cancers in males in order?

Answer 3

1. prostate
2. lung
3. colorectal

Question 4

What are the top 3 most common cancers in females in order?

Answer 4

1. breast
2. lung
3. colorectal

Question 5

What are the top 3 causes of cancer deaths in males in order?

Answer 5

1. lung
2. prostate
3. colorectal

Question 6

What are the top 3 causes of cancer deaths in females in order?

Answer 6

1. lung
2. breast
3. colorectal

Question 7

What is happening to incidence and death from colorectal cancer? why?

Answer 7

both declining b/c of screening

Question 8

What is happening to lung cancer incidence?

Answer 8

declining

Question 9

What 5 types of cancer associated with Li Fraumeni syndrome?

Answer 9

brain, breast, adrenal cortex, leukemia, sarcoma

Question 10

What gene associated with Li Fraumeni?

Answer 10

p53

Question 11

What gene assocaited with FAP?

Answer 11

APC

Question 12

What gene associated with MEN1?

Answer 12

MEN1

Question 13

What gene associated with MEN2?

Answer 13

RET

Question 14

What 3 cancers associated with MEN1?

Answer 14

• pancreatic islet
• pituitary adenoma
• parathyroid adenoma

TRIPLE P

Question 15

What 2 cancers associated with MEN2?

Answer 15

• medullary thyroid

- pheochromocytoma

Question 16

What 3 cancers associated with von hippel lindau?

Answer 16

• hemangioblastoma
• nervous system
• renal cell

Question 17

What mutation assoctated with cowden syndrome?

Answer 17

PTEN

Question 18

What 2 cancers associated with Cowden?

Answer 18

breast

thyroid

Question 19

What is sensitivity?

Answer 19

proportion of people with a disease who have a positive result on screening test

Question 20

What is specificity?

Answer 20

proportion of people who do not have a disease who have a negative result on screening test

Question 21

What property of test allows you to detect when a disease is present?

Answer 21

sensitivity

Question 22

What property of test allows you to correctly identify absence of disease?

Answer 22

specificity

Question 23

What is definition of positive predictive value?

Answer 23

proportion of people with a positive result on a screening tests who actually have the disease

Question 24

What is the negative predictive value?

Answer 24

proportion of people who have negative result on screening test who truly do not have the disease

Question 25

What is selection bias?

Answer 25

screening high risk population detect more cancer than general population

Question 26

What is lead time bias?

Answer 26

bias when survival from diagnosis to death appears increased but its b/c patients are diagnosed early but don’t actually live longer

Question 27

What is length bias?

Answer 27

when screening test diagnoses slow growth tumors. pts die from other causes with a particular tumor not FROM the tumor

Question 28

What type of cancer is MRI not a good study for evaluating?

Answer 28

lung cancer

Question 29

What does PET scan show you?

Answer 29

anatomic distribution of tumor and activity of lesions involved

Question 30

What does bone scan show you?

Answer 30

osteoblastic activity of metastasis