Lec 20 Oncology Intro Flashcards
What is median age of diagnosis new malignancy?
66
What are the top 2 leading causes of death in the US in order?
- heart disease
2. malignancy
What are the top 3 most common cancers in males in order?
- prostate
- lung
- colorectal
What are the top 3 most common cancers in females in order?
- breast
- lung
- colorectal
What are the top 3 causes of cancer deaths in males in order?
- lung
- prostate
- colorectal
What are the top 3 causes of cancer deaths in females in order?
- lung
- breast
- colorectal
What is happening to incidence and death from colorectal cancer? why?
both declining b/c of screening
What is happening to lung cancer incidence?
declining
What 5 types of cancer associated with Li Fraumeni syndrome?
brain, breast, adrenal cortex, leukemia, sarcoma
What gene associated with Li Fraumeni?
p53
What gene assocaited with FAP?
APC
What gene associated with MEN1?
MEN1
What gene associated with MEN2?
RET
What 3 cancers associated with MEN1?
- pancreatic islet
- pituitary adenoma
- parathyroid adenoma
TRIPLE P
What 2 cancers associated with MEN2?
- medullary thyroid
- pheochromocytoma
What 3 cancers associated with von hippel lindau?
- hemangioblastoma
- nervous system
- renal cell
What mutation assoctated with cowden syndrome?
PTEN
What 2 cancers associated with Cowden?
breast
thyroid
What is sensitivity?
proportion of people with a disease who have a positive result on screening test
What is specificity?
proportion of people who do not have a disease who have a negative result on screening test
What property of test allows you to detect when a disease is present?
sensitivity
What property of test allows you to correctly identify absence of disease?
specificity
What is definition of positive predictive value?
proportion of people with a positive result on a screening tests who actually have the disease
What is the negative predictive value?
proportion of people who have negative result on screening test who truly do not have the disease
What is selection bias?
screening high risk population detect more cancer than general population
What is lead time bias?
bias when survival from diagnosis to death appears increased but its b/c patients are diagnosed early but don’t actually live longer
What is length bias?
when screening test diagnoses slow growth tumors. pts die from other causes with a particular tumor not FROM the tumor
What type of cancer is MRI not a good study for evaluating?
lung cancer
What does PET scan show you?
anatomic distribution of tumor and activity of lesions involved
What does bone scan show you?
osteoblastic activity of metastasis
