Laz Nephritic and Nephrotic

Question 1

what is the key feature of nephrotic

Answer 1

LOTS OF PROTEIN in URINE

Question 2

What is the key feature of nephritic

Answer 2

Lots of PROTEIN AND BLOOD in urine

Question 3

What are causes of nephrotic syndrome

Answer 3

minimal change disease
membranous glomerulonephritis
diabetic nephropathy.

Question 4

What aetiology occurs in nephrotic disease

Answer 4

glomerulus becomes leaky > loss of protein > protein cannot be reabsorbed later by the kidney > lost in urine

Question 5

What is the triad of nephrotic disease

Answer 5

Proteinuria

Hypoalbuminaea (as albumin is one of the proteins lost)

Oedema (as loss of albumin causes change in osmotic gradient, causing loss of fluid into interstitum)

+ Thrombosis

Question 6

Why does nephritic syndrome occur

Answer 6

inflammation of glomerulus and nephron

Question 7

What are causes of nephritic syndrome

Answer 7

IgA nephropathy 
Post strep glomerulonephrosis 
Henoch Schonein Purpura 
HUS 
SLE 
Goodpastuyres

Question 8

Explain defining clinical features of post strep glomerulonephritis

Answer 8

4-6 WEEKS after group A strep (pharyngitis, skin) 
nephritic presentation (more HTN) 

Tx: Control BP

Question 9

Explain defining clinical features of IgA nephropathy

Answer 9

Localised to KIDNEY
Nephritic presentation (more proteinuria)
Abdo pain, rash, arthritis
5-7 DAYS after resp / GI infection

Question 10

explain features of Henoch Schonlein purpura

Answer 10

WIDESPREAD nephritis (due to ubiquitous deposition of IgA complex)

Purpuric rash
Arthritic
Abdo pain

After resp / GI infection

Question 11

How do you manage Henoch Schonlein purpura

Answer 11

spontaneous resolution

occasional steroids