Latency Period

Question 1

Latency period

Answer 1

the period of time which must elapse between the time at which a drug is absorbed the time at which a specified pharmacologic effect is produced.

Question 2

First pass effect

Answer 2

The first-pass effect is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall.

Question 3

Examples of psychiatric drugs which undergoes a significant first pass effect include:

Answer 3

imipramine
fluphenazine
morphine
diazepam
buprenorphine

Question 4

Examples which undergo little to no first pass include:

Answer 4

lithium

pregabalin

Question 5

Orally administered drugs undergo the most first pass effect. Routes which avoid the first pass effect include:-

Answer 5

Sublingual
Rectal (partly avoids first pass)
Intravenous
Intramuscular
Transdermal
Inhalation