Augmentation Of Clozapine Flashcards
1
Q
Should an adequate trial of clozapine fail to be of benefit, augmentation with additional antipsychotics or anti epileptics should be considered.
A
Sulpride and amisulpride are the favoured antipsychotics for augmentation with clozapine as their selectivity for D2 dopamine blockade compliments clozapine (which lacks high potency dopamine blockade).
2
Q
The Maudsley guidelines list the following options for clozapine augmentation:-
A
Amisulpride Aripiprazole Haloperidol Lamotrigine Omega-3-triglycerides Risperidone Sulpiride Topiramate Ziprasidone
3
Q
They specifically suggest avoiding using the following:-
A
Pimozide
Olanzapine
