Antidepressants (interactions)

Question 1

Many SSRIs have significant effects on the cytochrome P450 system.

Significant interactions include:-

Answer 1

Fluvoxamine and theophyliline (fluvoxamine is a potent inhibitor of CYP1A2 which can result in raised theophylline levels).
Fluoxetine and clozapine (fluoxetine is a potent inhibitor of CYP2D6 which can result in increased seizure risk with clozapine).