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Endocrinology > Last minutes > Flashcards

Last minutes Flashcards

1
Q

beta cells ___ the ATP gated K+ channel

A

close

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2
Q

alpha cells ___ the ATP gated K+ channel

A

open

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3
Q

GLP-1 (incretins) MOA

A
  1. STIMULATOR of insulin synthesis and release

2. Inhibits glucagon secretion, slows gastric emptying, and anorectic effect

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4
Q

SU MOA

A

CLOSING of the ATP sensitive K+ channel by sulfonylurea binding to the outside of the channel to result in insulin release from beta cells

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5
Q

metformin MOA

A

increases insulin sensitivity and decreases hepatic glucose production

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6
Q

metformin ADE

A

GI related

low B12 levels

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7
Q

thiazolidinediones MOA

A

insulin sensitizer in the peripheral, esp. adipose tissues

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8
Q

thiazolidinediones Contraindications

A

CHF

heptatocellular disease

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9
Q

rosiglitazone

A

MI risk

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10
Q

pioglitazone

A

bladder cancer

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11
Q

thiazolidinedione drugs

A

-litazones

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12
Q

SU drugs

A

-ides

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13
Q

SU contraindications

A

hypoglycemia –> no combo with insulin

sulfa allergy

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14
Q

glinides drugs

A

-glinide

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15
Q

glinide MOA

A

same as SU: closes ATP dependent K+ pump of the beta cell to induce insulin secretion

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16
Q

GLP-1 agonists drugs

A
  • tide
17
Q

GLP-1 agonists MOA

A

synthetic GLP-1 that induces synthesis of insulin and inhibits release of glucagon

18
Q

GLP-1 agonist CI

A

thyroid cancer/FH of thyroid

19
Q

DDP-4 inhibitors drugs

A

-liptin

20
Q

DDP-4 MOA

A

incresase patients levels of GLP-1

21
Q

weight gaining drugs

A

insulin
SU
thiaz

22
Q

weight inhibiting drugs

A

DDP-4

GLP-1

23
Q

SGLT-2 inhibitiors drugs

A

-gliflozin

24
Q

SGLT-2 MOA

A

lowers blood sugar to cause glucosuria by inhibiting the SGLT-2 pump

25
Q

SGLT-2 problems

A

increased infections, renal impairment patients would have problem, gangrene, amputations, expensive

26
Q

phenformin (like metformin)

A

causes lactic acidosis

Endocrinology (11 decks)

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