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Pathology Exam II > LAst minute > Flashcards

LAst minute Flashcards

1
Q

Ki67 or PCNA are indicators of what?

A

These are markers of tumor growth/proliferation.

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2
Q

Bizzare giant multinucleated cells are a hallmark feature for what type of tumor?

A

Hallmark feature for anaplasic tumors.

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3
Q

Expression of what on tumor cells will favor metastasis?

A

CD 44

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4
Q

What type of cancer typically causes osteoblastomas?

A

Prostate cancer.

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5
Q

What type of cancer will typically lead to Osteolytic metastasis?

A

PGE2 and IL-1 producing tumors.

Breast cancer will cause this as well.

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6
Q

What is the metastatic site for Stomach adenocarcinoma?

A

Virchows left supraclavicular node

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7
Q

What is the metastatic site for Renal adenocarcinoma?

A

Lung

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8
Q

What is the metastatic site for lung carcinoma?

A

Adrenal/liver

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9
Q

Which primary tumor commonly metastasizes to the brain?

A 
LUBGOM
Lung
Breast
Genitourinary
Isteosarcoma
Melanoma
GI
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10
Q

Which primary tumor commonly metastasizes to the liver?

A

Colon
Stomach
Pancrease

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11
Q

What primary tumor will metastasize to the bone?

A

PRostate, breast, lung, thyroud.

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12
Q

What is the Dukes system for staging?

A

Colorectal cancers

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13
Q

What is the Ann Arbor System for staging?

A

Hodgkin and non hodgkin lymphomas.

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14
Q

What does Nickel exposure put you at risk for?

A

Nose and lung cancer

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15
Q

What does radon exposure put you at risk for?

A

Lung cancer

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16
Q

What does vinyl chloride put you at risk for?

A

Angiosarcoma of the liver

17
Q

What does Aniline dies put you at risk for?

A

Bladder cancer sen in manufacturing of aniline dyes, textiles, and rubber work

18
Q

What neoplasm is associated with AIDS?

A

Malignant lymphoma

Kaposi Sarcoma

19
Q

What neoplasm is associated with Barret esophagus?

A

Esophageal adenocarcinoma

20
Q

What neoplasm is associated with chronic atrophic gastritis, pernicious anemia, postsurgical gastric remains?

A

Gastric adenocarcinoma

21
Q

What neoplasm is associated with Cushings syndrome?

A

Small cell lung cancer due to over expression of ACTH.

22
Q

What neoplasm is associated with Down syndrome?

A

ALL
and
AML

23
Q

What neoplasm is associated with Hypercalcemia?

A

Squamous cell lung cancer

24
Q

What neoplasm is associated with Polycthemia?

A

Renal cell carcinoma

Hepatocellular carcinoma

25
Q

What Neoplasm is associated with SIADH?

A

Small cell lung cancer

26
Q

What Neoplasm is associated with ulcerative colitis?

A

Colonic adenocarcinoma.

27
Q

What happens if Fibroblast growth factors (HST1) are over expressed?

A

Stomach cancer

28
Q

What happens if HGF is over expressed?

A

Thyroid cancer

29
Q

What happens if the receptor ERBB2 (HER-2/NEU) is over amplified?

A

Breast cancer

Ovarian Cancer

30
Q

What happens if the receptor for neutrophic factors (RET) receives a point mutation?

A

MEN 2A and 2B

Familial medulary thyroid carcinomas

31
Q

What happens if there is a point mutation in the KRAS gene?

A

Pancrease
Colon
Lung Cancer

32
Q

What happens if there is a translocation in the ABL ene?

A

Chronic myeloid leukemia

Acute lymphoblastic leukemia

33
Q

What happens if there is a point mutation or over expression of the B-catenin gene in WNT signalling?

A

Hepatoblastomas and

Hepatocellular carcinoma

34
Q

What happens if there is a translocation of the c-Myc gene?

A

Burkitt lymphoma

35
Q

What happens if there is an amplification of the N-myc gene?

A

Neuroblastoma

Small cell carcinoma of the lung

36
Q

What hapens if there is a translocation of the Cyclin D gene?

A

Mantle cell lymphoma

37
Q

What happens if there is an amplification of the Cyclin D gene?

A

Breast and esophageal cancer.

Pathology Exam II (14 decks)

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