Lab Evaluation Of Liver Cell Injury Flashcards
UCB is also called ________ bilirubin which is lipid soluble.
Indirect
CB is also called ________ bilirubin which is water soluble.
Direct
Intestinal bacteria convert CB to ___________
Urobilinogen (stercobilinogen)
Urobilinogen is spontaneously oxidised to ________
Urobilin (stercobilin)
________ gives brown color to stool
Urobilin
____% of urobilinogen in intestine is recycled to the liver
20%
Jaundice is first noticed in the ______ because it has high affinity for bilirubin
Sclera
Classification of the causes of jaundice is based on the percentage of ________ bilirubin
Conjugated bilirubin
Give the classification of jaundice acc. to percent CB
- Unconjugated hyperbilirubinemia (<20%)
- Mixed hyperbilirubinemia (20-50%)
- Obstructive liver disease (>50%)
What are the causes of unconjugated hyperbilirubinemia?
Extravascular hemolytic anemia (hereditary spheroc.)
Decreased liver uptake (taking rifampicin)
Decreased conjugation of UCB (phys. jaundice of newborn, gilbert syn., criggler nijjar synd.)
Drugs (like sulfonamide, penicillin)
Breast milk jaundice
What are the causes of mixed hyperbilirubinemia?
Viral hepatitis
What are the causes of obstructive liver disease?
Cirrhosis
Gallstone blocking common bile duct
Serum ALT is specific enzyme for ____________
Liver cell necrosis
In viral hepatitis, AST will be _______ (more/less) than ALT.
Less
Serum AST will be increased in _____________
Alcoholic hepatitis