Autoimmune and Drug induced Hepatitis

Question 1

Define AIH

Answer 1

Autoantibodies
Hypergammaglobinemia
Ngeative viral serologies

Question 2

AIH affects _________ (men/women) more

Answer 2

women

Question 3

What r the types of AIH?

Answer 3

Type 1 = Middle aged and elder

Type 2 = teenagers and children

Question 4

what is the epidemiology of AIH?

Answer 4

affects women
less than 40 mostly
triggers (viral inf/drugs like halothane)
HLA DR3 and DR4
Concurrent autoimmune disease (HT and GD)

Question 5

What r the clinical findings of AIH?

Answer 5

Fever
Jaundice
Hepatosplenomegaly

Question 6

What r the lab findings in AIH type 1?

Answer 6

ANA
Anti-SLA/LP
Anti-SMA
AMA
Increased transaminases

Question 7

What are the lab findings in AIH type 2?

Answer 7

ANA is negative
Anti LKM antibodies
Anti LC1- Antibodies (ACL-1)

Question 8

Morphological features of AIH?

Answer 8

Early severe parenchymal injury
Perivenular/bridging necrosis
Scarring (might be early or late)
Rossetes of hepatocytes
Plasma cell predominences

Question 9

What is tx of AIH?

Answer 9

Immunosuppressive therapy

Question 10

__________ causes cholestasis in only those patients who are too slow to metabolize it

Answer 10

chloramprazine

Question 11

___________ causes AIH (drug)

Answer 11

Halothane