Lab 7: Acute Inflammation Flashcards
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- What is 1
- 2
- 3
- Pleura
- Subpleural lymphatics
- Interlobular lymphatics
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- What is 4?
- 5?
- 6?
- 4- Lymphatic with edema
- 5- Alveolar hyperemia
- 6- Alveolar edema (with increased protein)
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- What is the pale pink material in alveoli?
- What are the dilated clear spaces?
- Edema fluid that has some increase in protein (hence the pink color)
- These are lymphatics in the interlobular septa that are filled with and expanded by edema fluid. They are more evident because they are serving to carry away the excess fluid present in the lungs.
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- Give a possible cause of this lung lesion.
- A lesion on the left AV valve causing insufficiency or stenosis of this valve would lead to increased back pressure into the pulmonary veins and pulmonary capillaries leading to increased hydrostatic pressure in post capillary venules and capillaries resulting in edema.
- Something wrong with the muscle of the left ventricle could also cause this.
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- What would this lung look like grossly?
- Grossly the lung would look diffusely dark red (venous congestion) and would be heavy and wet with expansion of the interlobular lymphatics with clear fluid (edema).
- Foamy pink material (pulmonary and tracheal edema fluid) might be found in the lumens of the bronchi.
Lung, porcine. Clinically the pig may have had a left side heart murmur.
- Histomorphologic diagnosis?
Moderate diffuse pulmonary congestion (passive hyperemia) and edema
Artery, canine
- What is 1?
- 2
- 3
- Artery wall
- Granulation tissue
- Arteritis
Artery, canine
- What is 4
- 5
- 6
- 7
- 4- Luminal thrombus
- 5- Lines of Zahn
- 6- Fibrin
- 7- Leukocytes from blood
Artery, canine
- What are possible sequelae if fragments of this thrombus were to break free into the arterial lumen (antemortem of course)? Chose a location for the thrombus to elaborate on the consequences or assume that this is right renal artery
- Mesenteric artery?
- What will happen if there is bacteria in the thrombus?
- The consequences of embolism occurring from this thrombus depend on where the thrombus is. If it is in the renal artery, emboli will lodge downstream and cause infarction of all or part of the kidney, depending on the size of the embolus and the size of the vessels occluded.
- If the embolus goes into a mesenteric artery, there may or may not be vascular compromise to a section of gut depending on the degree of collateral circulation. It is conceivable that no noticeable affect may occur.
- Because there are bacteria present, where ever the embolus comes to rest, it can cause another site of infection and possibly abscess formation.
How would you name this arterial lesion?
Arterial thrombus (chronic) with chronic arteritis
Nasal mass, horse. This specimen is from a mass that has been present in the nasal cavity of a horse for several weeks. Because of the mass, the horse has exhibited epistaxis.
- What is 1?
- 2
- 3
- Nasal epithelium
- Fibrosis (from granulation tissue)
- Hemorrhage resulting in a mass–hematoma
Nasal mass, horse. This specimen is from a mass that has been present in the nasal cavity of a horse for several weeks. Because of the mass, the horse has exhibited epistaxis.
- The mass is covered by stratified squamous epithelium. If this epithelium should be ciliated, pseudostratified, columnar epithelium, what do you term this alteration?
Squamous metaplasia of nasal mucosa.
Nasal mass, horse. This specimen is from a mass that has been present in the nasal cavity of a horse for several weeks. Because of the mass, the horse has exhibited epistaxis.
- What is the term for the free blood in the tissue?
Hemorrhage, which when it forms a swelling is a hematoma.
Nasal mass, horse. This specimen is from a mass that has been present in the nasal cavity of a horse for several weeks. Because of the mass, the horse has exhibited epistaxis.
- What is the arrow pointing at?
- How did it get there?
- Hemosiderin containing macrophages
- Phagocytosis of free red blood cells by macrophages resulted in breakdown of hemoglobin.
- You will recall that heme is processed to biliverdin and bilirubin while the iron component is processed to hemosiderin seen here.
Nasal mass, horse. This specimen is from a mass that has been present in the nasal cavity of a horse for several weeks. Because of the mass, the horse has exhibited epistaxis.
- What is 1?
- How did 1 get there?
- 2?
- Hematoidin
- The yellow pigment is local bilirubin (sometimes termed hematoidin when seen in tissue histologically), an early breakdown pigment when there are large areas of hemorrhage.
- Hemosiderin in macrophage