L9-L10 Nervous Tissue I and II Flashcards

1
Q

What do the functions of the nervous tissue coordinate?

A

Body function with environment (external & internal)

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2
Q

What is the organization of the nervous system?

A

Structural and Functional

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3
Q

What are two parts of the structural organization of the nervous system? What things are they associated with?

A

2 parts: 1. CNS, 2. PNS
CNS: gray matter and nuclei, white matter and tracts
PNS: ganglia, nerves

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4
Q

What are 2 parts of the functional organization of the nervous system? What are they associated with?

A

Somatic and autonomic
Somatic: Sensory (afferent), Motor (efferent)
Autonomic: Parasympathetic, Sympathetic

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5
Q

What is the CNS compose of?

A

Brain, Spinal Cord

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6
Q

What is the PNS consisted of?

A

Cranial nerves

Spinal nerves

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7
Q

What are the types of nerve fibers (axons)?

A

Somatic system, visceral system, somatic axons, autonomic axons

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8
Q

What is a somatic system? Examples?

A

Functions that relate to external environment (eg pain, locomotion)

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9
Q

What is a visceral system? Examples?

A

Functions that relate to internal environment (eg heart rate, digestion)

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10
Q

What are somatic axons?

A

Sensory and motor

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11
Q

What are autonomic axons?

A

Sympathetic and parasympathetic

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12
Q

What is exclusive about autonomic axons?

A

Regulation of visceral activity and responsible to make the organs do more or less of something

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13
Q

What are 2 fundamental cells in nervous tissue?

A

Neurons (functional cells), and Glial cells (support cells)

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14
Q

What is a neuropil?

A

Synaptically dense regions composed of unmyelinated axons, dendrites and processes of glial cell in CNS gray matter; there is also NO connective tissue integrated into CNS

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15
Q

What is a neuron? What is its primary function?

A

Functional unit of the nervous system.

Its primary function is to generate and propagate action potentials

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16
Q

What are neuron PARTS?

A

Cell body, dendrite(s), axon

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17
Q

What are the main types of neurons?

A

Bipolar (retina, cranial nerve VIII), multipolar (99% of all neurons), and pseudounipolar (sensory ganglia)

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18
Q

What are the bipolar types of neurons?

A

Limited to visual, auditory, vestibular pathways: one dendrite, one axon

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19
Q

What are the pseudounipolar types of neurons?

A

They are confined to spinal nerve sensory ganglia and some cranial nerves

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20
Q

What is significant about the spinal nerve?**

A

Pseudounipolar->collecting sensory info from body wall -> deliver back to CNS

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21
Q

What is significant about multipolar neurons?

A

All remaining neurons (99% of all neurons) have 2 to many dendrites, one axon

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22
Q

What is a unique cell of the multipolar neurons?

A

Pyramidal cell

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23
Q

What cell of the multipolar neuron is exclusive to cerebellum?

A

Purkinje cell

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24
Q

Multiple dendrites form an ______ to neuron.

A

Inflow

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25
Q

Axon forms an ___ of the neuron.

A

Outflow

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26
Q

What is the target of a neuron?

A

Another neuron, muscle, gland

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27
Q

What is the cell body (perikaryon/soma) of neuron?

A

Contains nucleus, nucleolus, Nissl bodies (rough ER, free ribosomes), Golgi complexes, mitchondria, neurofilaments, microtubules

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28
Q

What are dendrites?

A

Contains same organelles as cell body except nucleus, Nissl bodies and Golgi complexes only in proximal portion

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29
Q

What are dendritic spines and what is significant about them?**

A

They are spines that come outwards and they serve to increase Surface area of the function in order to receive more of neurotransmitters from another axon

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30
Q

____ has a more prominent nucleolus?

A

Euchromatic

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31
Q

Cytoskeleton and secretory vesciles pass from _____ to the _____.

A

Cell body to the axon

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32
Q

What is the initial segment of the axon? What is generated there?

A

Between axon hillock and beginning of myelin sheath. Axon potentials are generated there

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33
Q

What are the nodes of Ranvier?

A

Allow axon to interact with cellular fluid around it

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34
Q

What is axonal (axoplasmic) transport? What direction does it go?

A

Movement mechanism of mitochondria, lipids, synaptic vesicles to and from cell body and axon; bidirectional

35
Q

What is anterograde axon transport?

A

away from cell body (cell prod returns to nucleus)

36
Q

What is retrograde axon transport?

A

Toward cell body; toxins like tetanus or viruses like canine herpes simplex (leading cause of death in newborn puppies), rabies, can travel CB

37
Q

What is the speed of each type of transport: anterograde transport? Retrograde transport?

A

Anterograde: fast or slow; retrograde: just fast

38
Q

What are the characteristics of fast transport? (3)

A
  • Utilize microtubules and motor proteins
  • Occur fairly rapidly: 20-400 mm/day
  • Transport organelles, synaptic vesicles etc.
39
Q

What are the characteristics of slow anterograde transport?

A
  • Occurs slowly: 0.2-4mm/day

- Transports cytoskeletal precursors & elements (tubulin, actin etc)

40
Q

What is a function of nervous tissue?

A

Integrates sensory (afferent) input with motor (efferent) output

41
Q

What are neurofilaments?

A

Intermediate filaments of neurons that provide structural support to the cell (cytoskeletal structures)

42
Q

What are microtubules?

A

Also cytoskeletal, but grown and shrink to move material around

43
Q

What is Lyssavirus transmitted by?

A

Rabies transmitted by virus-laden saliva

Virus travels along peripheral nerves, to spinal cord, to brain , out through peripheral nerves to salivary gland

44
Q

The myelination of axons is electrically insulating what?

A

Sheath that can surround axons

45
Q

What does the myelination of axons improve?

A

Conduction velocity of medium and large-sized axons

46
Q

There is NO myelin at: ____ and _____.

A

Initial segment and axon terminals

47
Q

What are internodal segments?

A

Regions where myelin present (insulated)

48
Q

What are Nodes of Ranvier?

A

Points between internodal segments (axon exposed)

49
Q

What is a saltatory conduction?

A

AP “jumps”from node to node

50
Q

What makes up the gray matter? White matter?

A

Gray: cell bodies
White: axons

51
Q

What is the myelin sheath?

A

Compressed layers of glial cell plasma membrane

52
Q

What does the myelin sheath do to the axon?

A

Wraps around tightly multiple times so that the cytoplasm is constrained to most superficial region

53
Q

The phospholipid portion of myelin at LM is lost- what does it leave behind?

A

Leaves clear (or very pale) region where myelin was present

54
Q

What are unmyelinated axons?

A

Axons with smaller diameters that require slower conduction velocities.
They are enveloped by glial cell, but NOT wrapped by the glial cell

55
Q

What are synapses?

A

Interneuronal connetions- communication

Cells separated by a narrow gap, synaptic cleft.

56
Q

What does the action potential of synapses initiate?

A

Action potential initiates neurotrans release -> crosses -> either depolarizes postsynpatic membrane (new AP) or hyper polarizes and inhibits

57
Q

What are the three types of connections?

A
  1. Axodendritic
  2. Axosomatic
  3. Axoaxonic
58
Q

What do the neuromuscular (myoneuronal) junctions do?

A

Causes buttons to talk, release contents, which then open up NA channels

59
Q

All synapses possess _____ and _____ elements

A

Presynaptic and postsynaptic elements

60
Q

What are glia cells?

A

Interstitial, supportive cells for neurons within the CNS

61
Q

What is the difference between oligodendrocytes, Schwann cells, astrocytes, microglia cells?

A

Oligodedrocytes, astrocytes, and microglia are part of CNS while Schwann cells are part of PNS

62
Q

What are features about astrocytes?

A

They have “feet” that help support:

  1. The blood-brain barrier
  2. The glia limitans: barrier between pia mater and the CNS
63
Q

What are oligodendrocytes?

A

Can myelinate more than one axon and more than one internodal segment per axon

64
Q

What is CNS myelin composed of?

A

Oligodendrocytes and differs from PNS myelin that is composed of Schwann cells

65
Q

What percentange of Microglia cells are in CNS?

A

10-15%

66
Q

Where are microglia from?

A

Descend from the mononuclear phagocyte system

67
Q

What is significant about microglia cells? (what can they become, what do they remove, and what is the rule of thumb)? (3)

A
  1. They can become phagocytic and antigen-presenting cells
  2. They remove damaged neurons and infectious agents
  3. Rule of Thumb: microglia form the primary immune defense of CNS
68
Q

The peripheral nerves are ___ and ___?

A

Motor and sensory

69
Q

What are ganglia?

A

Collections of functionally-related neuronal cell bodies

70
Q

What part of the ganglia is sensory?

A

Dorsal root ganglia

71
Q

What does the ANS contribute?

A

Motor ganglia

72
Q

What is housed in the CNS?

A

Somatic motor cell bodies

73
Q

What are peripheral nerves?

A

Collections of functionally- related nerve fibers (axons)

74
Q

What are Satellite Cells?

A

Glial cells (neural crest) that form a complete ring around the pseudounipolar neuron

75
Q

What is the CT capsule?

A

Nerve fiber (NF) bundles (cell bodies in clusters)

76
Q

What does peripheral nerves do?

A

Appear “Wavy”

77
Q

What are Schwann cells limited to?

A

ONE internodal segment on ONE axon

78
Q

What is significant about Schwann cells?

A

Has an external lamina

79
Q

What is CNS myelin composed of and what does it differ from?

A

Composed of oligodendrocytes and differs from PNS myelin that is composed of Schwann cells

80
Q

What are the important structures of the connective tissue of peripheral nerves?

A
  1. Epineurium
  2. Perineurium
  3. Endoneurium
81
Q

What is the meaning of epineurium?

A

Fibrous coat around whole nerve- also fills space between nerve fibers (dense, irregular connective tissue)

82
Q

What is the definition of perineurium?

A

Surrounds each bundle of nerve fibers

83
Q

What is the definition of endoneurium?

A

Envelops the myelin sheaths of individual axons. Composed of reticular fibers produced by the Schwann cells