L8- CNS: Pain and Drug Addiction Flashcards
*Which sensory nerves mediate “fast or acute pain” responses
a. A-alpha fibers
b. A-beta fibers
c. A-delta fibers
d. C fibers
e. Optic Nerve
c. A-delta fibers
*A major cellular action of opioid receptors is to suppress:
a. cAMP
b. PKC
c. Na+ channels
d. Arachidonic acid metabolism
e. Transcription
a. cAMP
*An opioid drug likely to cause addiction would
a. Enter the CNS very rapidly
b. Have a very long half-life
c. Be an opioid receptor antagonist
d. Be more effective taken orally
e. None of the above is true
a. Enter the CNS very rapidly
Which sensory nerves mediate “slow or inflammatory pain” responses?
A. A-alpha fibers
b. A-beta fibers
C. A-delta fibers
D. C fibers
E. optic nerve
D. C fibers
A major cellular action of opioid receptors is to suppress:
A. voltage-gated Ca2+ channels
B. PKC
C. Nitric oxide
D. Arachidonic acid metabolism
E. DNA transcription
A. voltage-gated Ca2+ channels
These 2 drugs are metabolized into morphine:
A. aspirin and ibuprofen
B. aspirin and codeine
C. codeine and heroin
D. aspirin and heroin
E. none of the above
C. codeine and heroin
Select the false statement
a. C-fibers have a prolonged hypersensitivity and fire continuously at a low rate and are responsible for the dull constant pain we may experience with some injuries, such as a sunburn
b. A Delta fibers are less myelinated because they cover a larger area and it reduces the energy cost required to myelinate such a large amount of nerves
c. A alpha and A beta fibers have a large diameter which causes them to conduct action potentials at slower rates
d. A delta and C fibers are sometimes called nociceptors
e. A alpha and A bete fibers are responsible for sensing and responding to touch
c. A alpha and A beta fibers have a large diameter which causes them to conduct action potentials at slower rates
Which of the following is NOT a clinical limitation of opioids?
a. Constipation
b. Increased likelihood to develop drug tolerance
c. Causes euphoria and becomes addictive
d. Trouble sleeping
e. None of the above.
d. Trouble sleeping
The following opioid does not enter the brain as quickly because of the additional alcohol groups in its molecular structure
a. Heroin
b. Codeine
c. Morphine
d. Fentanyl
e. Sufentanil
c. Morphine
This analog is typically given as an end-of-life treatment and when injected into the spinal cord it can delete pain fibers permanently
Capsaicin Toxin
Explain why alpha delta fibers are not as myelinated as touch fibers
Alpha Delta fibers cover a large area so they are lightly myelinated in order to reduce the energy cost.
- Rather have areas of with low speed than areas with no speed at all.
What is the molecular reason that heroin reaches the brain faster than morphine?
The acetyl groups allow heroin to rapidly enter the brain once it is in the brain it is deacetylated and becomes morphine.
- Morphine does not enter the brain as quickly because of the hydroxyl groups.
