L13- Anti-inflammatory drugs and Immunosuppressants Flashcards
Mast cells release ____ in response to antigens and macrophages release ____ ____.
Mast cells release HISTAMINE in response to antigens and macrophages release OXYGEN RADICALS
This anti-inflammatory drug irreversibly inhibits COX-1 and can block platelet production and reduce clotting.
BABY ASPRIN
Inflammation occurs because of
a. Physical injury
b. The body’s attempt to prevent infection
c. Bacteria and pathogens reaching the epithelial infection
d. The adaptive immune system response alone
e. A response to stress
C. Bacteria and pathogens reaching the epithelial infection
The Adaptive immune system involves which cells
a. Helper T cells
b. Neutrophils
c. Macrophages
d. Mast cells
e. Natural killer cells
a. Helper T-Cells
Select the true statement.
a. Acetaminophen is anti-inflammatory and can be classified as an NSAID
b. Acetaminophen inhibits COX-1 irreversibly which can decrease the rate of cell turnover in the gut.
c. Acetaminophen has analgesic effects
d. Acetaminophen increases the risk of bleeding because it inhibits platelet aggregation
e. Acetaminophen blocks the conversion of arachidonic acid to prostaglandin
C. Acetaminophen has analgesic effects
T-cell inhibitors such as cyclosporin
a. Are given to prevent transplant rejection and severe auto-immune conditions
b. Given to treat allergic reactions
c. Used as a part of treatment for immunotherapy
d. Are given to increase production of corticosteroids
e. Prevent the differentiation of monocytes into macrophages
a. Are given to prevent transplant rejection and severe auto-immune conditions
*The analgesic action of NSAIDs are due to
Inhibition of COX-2
*Main side effect of Antihistamines
SEDATION
*This cytokine is a major target for antiinflammation treatment
TNF-alpha
*Arachidonic Acid is the precursor for
PROSTAGLANDS AND LEUKOTRIENES
What does the Dendritic cells do in Innate immunity?
Mediate NEW immune responses
by presenting Antigen to T cell
Pharmacology of Asprin
Inhibit COX-1 irreversibly and modify Cox2
(Also anticoagulant factors in baby aspirin)
Pharmacology of Ibuprofen
Block Cox1 and Cox2
COX-1 vs. COX-2
Cox1
- responsible for cell proliferation
- has low levels normally
Cox2
- drives inflammation and blocking it allows analgesia effects
- Hella upregulated during inflammation
T-Cells Inhibitors
(Cyckisoirub, FK506)
Blocks CALCNEUNIN (ca2+ activated phosphatase)
-> allows dephosphorylation of NFAT needed for translocation to neuron and Interleukin 2 (IL2) transcription
= BLOCK T CELL FROM REJECTION
Anti-CD3 Antibody
(Murcmnb CD3)
Stimulation of only 1 or 2 signals for t-cell activation -> inactivate T-cell
Anti-CD80 Antibody
Block co-stimulation of T-cell
(used in RA)
