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MoD > L8 - Chronic Inflammation > Flashcards

L8 - Chronic Inflammation Flashcards

1
Q

acute inflammation is innate or adaptive immunity?

A

innate

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2
Q

chronic inflammation is innate or adaptive immunity?

A

both

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3
Q

which type of inflammation as an onset of hours/days?

A

acute

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4
Q

which type of inflammation as an onset of weeks/months/years?

A

chronic - easily missed sometimes due to this

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5
Q

angiogenesis and fibrosis are characteristics of which type of inflammation?

A

chronic

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6
Q

blood vessel dilation and increased permeability are characteristics of which type of inflammation?

A

acute

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7
Q

fluid exudation is a characteristic of which type of inflammation?

A

acute

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8
Q

neutrophils, mast cells and macrophages are characteristic cells of which type of inflammation?

A

acute

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9
Q

macrophages, lymphocytes and plasma cells are characteristic cells of which type of inflammation?

A

chronic

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10
Q

what are characteristics of acute inflammation?

A

rubor calor tumour dolor

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11
Q

what are characteristics of chronic inflammation?

A

amyloidosis cachexia anemia

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12
Q

what is chronic inflammation?

A
  • inflammation of prolonged duration - concomitant tissue destruction and repair - mononuclear inflammatory cells - fibrosis
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13
Q

what are the circumstances under which chronic inflammation arises?

A
  1. progression from acute 2. recurrent episodes of acute 3. persistent infection 4. prolonged exposure to toxic agents 5. autoimmunity 6. unknown
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14
Q

chronic pyelonephritis can occur due to what?

A

persistent infection

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15
Q

chronic inflammation can arise due to prolonged exposure to toxic agents such as?

A
  • alcohol - obesity - hep B/C - asbestos
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16
Q

rheumatoid arthritis is chronic inflammation due to what?

A

autoimmune disease

17
Q

what is the difference between a monocyte and a macrophage?

A

same cell “monocyte” when in blood “macrophage” when in tissue

18
Q

what are different types of macrophages?

A
  • microgila (CNS) - kupuffer cells (liver) - alveolar macrophages (lung) - osteoclasts (bone)
19
Q

what are the roles of an activated macrophage?

A
  • phagocytosis - production of factors that stimulate angiogenesis
20
Q

what is a granuloma?

A
  • collection of activated epithelioid macrophages (pink cytoplasm, indistinct cell membranes, oval nucleus) - Surrounded by mononuclear leucocytes - Caseating or non-caseating - May also contain multinucleate giant cells
21
Q

what cells do you find in connective tissues?

A

mast cell fibroblast macrophage

22
Q

what cells do you find in vessels?

A
  • polymorphonuclear leukocyte - lymphocyte - platelets - monocyte - clotting factors (cytokines complement proteins etc) - eosinophils - basophils
23
Q

what will an early granuloma look like?

A
  • macrophage core - surrounded by lymphocytes (B and T cells)
24
Q

what will a caseous epitheloid granuloma look like?

A
  • caseous necrosis core - surrounded by macrophages - surrounded by lymphocytes (B and T cells) - surrounded by fibroblasts producing collagen
25
Q

what will a non-caseous epitheloid granuloma look like?

A
  • macrophage core - surrounded by lymphocytes (B and T cells) - surrounded by fibroblasts producing collagen
26
Q

what cell is this?

A

eosinphill

dotty cytoplam

multi lobed nuclei

red tomato wearing sunglasses

27
Q

when would you see a eosinophil or mast cell?

A

during an allergic response

28
Q

what cell is this?

A

mast cell

dense, purple

29
Q

what cell is this?

A

lymphocyte

dense large nuclei/takes up whole cell

30
Q

what cell is this?

A

plasma cell

dotty nucleus - chromatin is clumped

nucleus positioned at one end of cell

31
Q

what cell is this?

A

fibroblasts

long cigar shaped

32
Q

what cell is this?

A

monocyte

bean shaped nuclei

33
Q
A

MoD (19 decks)

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