L7: Drugs in FA Flashcards
what are the 3 uses for drugs in food animals
- prophylactic or metaphylactic prevention of morbidity/mortality
- treat illness
- increase production
when a drug is administered to any animal, we indirectly also administer that drug and its metabolites to ______ and _______
people and local environment
drug that cannot ever be used in food animals, causes fatal aplastic anemia in humans
Chloramphenicol
broad spectrum antibiotic that crosses the BBB and placenta
antibiotic that kills bacteria used in dairy product manufacturing
cannot be used in lactating dairy cows
**Enrofloxacin **
broad spectrum antibiotic of fluoroquinolone class
target tissues are _____ tissues, typically the ______ or ________
edible
liver or kidney
_______ is a line below which ANY and ALL food pdts from an animal are considered to have TOTAL drug+metabolite levels that are SAFE for consumption
Tolerance
what is evaluated to determine ‘safe for consumption’
- carcinogenic potential
- systemic, reproductive, developmental toxicities
- potential to cause antibiotic resistance
What identifies as a food animal residue
a drug OR regulated metabolite that is identified in a defined target tissue at or above tolerance
The amounts of all drugs+pesticides in food animals at slaughter are regulated by the _______
fed government
* Dept Health&Human Services
* FDA
* Center for Veterinary Medicine (CVM)
* EPA
what is withdrawal time
- THE time required for a drug or metabolite to be below the tolerance level
- in the 99th percentile of the population
- with 95% confidence
for EVERY drug used in food animals, the center for veterinary medicine regulates….
- species
- indication for use
- dose
- route of entry
- interval of administration
what drug groups are of greatest concern
- pesticides, fungicides, insecticides
- antibiotics
these are most commonly in violation b/c they represent the greatest risk of exposure
Additives that can be given to animals without regulation are on the ______ list
GRAS
Generally Regarded As Safe
the GRAS list includes items fed to animals such as….
- mineral additives to feeds
- adjuvants added to pesticides
- items that can be added to food after slaughter
The Veterinary Feed Directive Final Rule intends to limit antibiotic use for ________ instead of production purposes
Therapeutic
