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MDSC404 Renal > L6: Tubular Function 3 > Flashcards

L6: Tubular Function 3 Flashcards

1
Q

What is the filtered load?

A

How much is coming into the tubule

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2
Q

Filtered load “s” =

A

Filtered load “s” = GFR x plasma concentration (Ps)

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3
Q

Excretion rate =

A

Excretion rate = V x urinary concentration (of a specific solute)

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4
Q

Fractional excretion (FE) =

A

FEs = excretion rate of s/ filtered load of s

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5
Q

The PST secretes __

A

organic anions (OA)/ organic cations (OC)

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6
Q

The PCT, TAL, IC secretes___

A

NH4,H,HCO3

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7
Q

CD principal cells secrete __

A

K (aldosterone)

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8
Q

What is the site of secretion of organic compunds?

A

PST

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9
Q

OAT

A

Organic anion transporters

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10
Q

Some OATs are depend on

A

dependant

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11
Q

How can we transport many OA?

A

The OATs have low specificity so transport of many

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12
Q

The secrtion of OA is linked to ___

A

alpha-KG

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13
Q

What do OAs compete for?

A

secretory pathways

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14
Q

What is the ATP dependent pathway in OC secretion?

A

MDR1

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15
Q

For cations we only need ___ type of transporter

A

1

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16
Q

MATE

A

multi drug and toxin exchanger

17
Q

Where is the OCT2?

A

on the basolateral membrane

18
Q

Where is the rate limiting step ____? why?

A

on the apical membrane because MDR1 is ATP-dependant

19
Q

Is organic cation transport specific?

A

no it is non-specific or polyspecific (can pretty much carry any organic cations)

20
Q

Give two examples of endo and exo OC and OA secreted by PST

A

OA
endo - creatinine, Bile salts
exo - Penicilin G, PAH

OC
endo- Dopamine, histamine
exo- Morphine, NMN

21
Q

Aldosterone promotes ___ secretion in ____ _____

A

K+, prinicipal cells

22
Q

Aldosterone is a steroid so it can move thorugh cells

A

passively through diffusion

23
Q

4 steps of aldosterone PE

A
  1. Diffuses into cell (CollectingD)
  2. Binds to Mineralcorticoid recpetor)
  3. Synthesis of mRNA for ENaC (epithelial sodium channel) and Na/K ATPase
  4. Increase NaR
24
Q

What are the 3 functions of aldosterone?

A

Increasing ATPase
Increaseing ENaC
Increasing ability of potassiom to move through K channels

25
Q

Aldosterone promtoes Na ____ and K _____

A

Na - rabs
K - sec

26
Q

What is the antagonist of aldosterone?

A

sprionolactone

27
Q

Summary steps of K secretion

A
  1. increase K
  2. increase aldosterone
  3. Increase K sec in collecting duct
  4. increase K excretion
28
Q

What is the main electrolyte of the ICF?

A

K

29
Q

What is the main electrolyte of the ECF?

A

Na

30
Q

osmolality

A

ability to pull water

31
Q

Disturbances in the ____ volume can lead to CV imbalance

A

ECF

32
Q

Hypernatremia

A

a dangerous rise in plasma Na
If you only drank sea water

MDSC404 Renal (8 decks)

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