L5: Tubular Function 2

Question 1

The kidney is not a plasma membrane instead it is a membrane across ____ cells

Answer 1

epithelial

Question 2

What are diuretics?

Answer 2

A diverse group of chemical compunds that promote Na excretion. When we lose sodium we pull water with it

Question 3

Why are diuretics used in clinical medicine?

Answer 3

To treat ECF accumulation (edema)

Question 4

How are diuretics classified?

Answer 4

According to site of action in tubule

Question 5

PCT diuretics

Answer 5

I osmotic diuretics
carbonic anhydrase inhibitors

Question 6

TAL diuretics

Answer 6

II loop diuretics

Question 7

DCT diuretics

Answer 7

III thiazide diuretics

Question 8

CD-principal cell diuretics

Answer 8

IV potassium sparing diuretics

Question 9

Diuretic ___ urinary flow rate

Answer 9

increases

Question 10

What is the purpose of diuretics

Answer 10

increase water excretion (alters NaR)

Question 11

What is an antidiuretic?

Answer 11

reduces water excretion

Question 12

Filtered load =

Answer 12

Filtered load = GFR x [P]s

Question 13

Transcellular and paracellular

Answer 13

through , b/w

Question 14

NHE3

Answer 14

important for Na and H exchange

Question 15

SGLT2

Answer 15

sodium and glucose transport - 1:1 ratio

Question 16

What is NHE3 regulated by? 2

Answer 16

SNS
ANg II

Question 17

AngII is a vaso____ and also the #1 regulator of

Answer 17

const, NaR

Question 18

SGLT2 is found on the __ membrane and GLUT2 is on the ____ membrane (90%)

Answer 18

apical, basolateral

Question 19

The capacity of ___ is exceeded in DM and is related to ___

Answer 19

SGLT2, gluosuria (eating more sugars than the body can process)

Question 20

Mutations in __ can cause glucosuria

Answer 20

GLUT2

Question 21

Defect in PCT can lead to . Ex of defect

Answer 21

proteinuria - megalin receptor

Question 22

There are numerous aa transporters on the ___ and ____

Answer 22

apical, basolateral

Question 23

Proteins and peptides are ____ and released as ___

Answer 23

endocytosed, aa’s

Question 24

NaR - Late PCT
Paracellular
mostly ___

Answer 24

diffusion

Question 25

PCT NaR is enhanced by __ and __ through ___

Answer 25

Ang II, SNS, NHE3

Question 26

What is the site of action for CA inhibitors (d class 1)

Answer 26

Proximal nephron