L6:The pharmacology of asthma Flashcards
asthma is
bronchoconstriction
how long does allergic asthma take to develop
15 mins
pathology of allergic asthma=
antigen binds 2 IgE on mast cell causing degranulation of mast cell
degranulated mast cell releases
histamine
leukotrienes
main bronchocontrictor in allergic asthma-
leukotrienes
what reverses bronchocontriction
beta agonists
what do beta agonists work on
beta adrenergic receptors
Sort acting beta agonist=
salbutamol
long acting beta agonists=
salmeterol
formoterol
most important cells in allergic component of allergic asthma
eosinophils
5 cells involved in asthma
APC CD4+ B-cells mast cell eosinophils
what recruits eosinophils
leukotriene from mast cells
where do steroids bind
receptors inside the cell
what do steroids cause apoptosis of
eosinophils
e.g of inhaler steroid
beclomethasone
first step in asthma treatment
give salbutamol (blue inhaler)
beta agonists cause
bronchodilation
smooth muscle relaxation
if using blue inhaler more than 3 times a day give
low dose inhaled corticosteroid
if still severe symptoms after inhaled steroid
-long acting beta agonist/ combination inhaler (symbicort)
symbicort=
budesonide
formoterol
severe symptoms after all previous treatment
prednisolone or
leukotriene antagonist or
theophylline
leukotriene antagonist=
montelukast
when montelukast is combined with steroids what happens
blocks duel pathways of inflammation
theophylline=
methylxanthine
smooth muscle relaxant
