L2: intrathoracic malignancy Flashcards
two primary intrathoracic malignancys
lung
pleura
lung malignancy=
carcinoma (>90%)
pleura malignancy=
malignant mesothelioma
90% of cases of lung cancer caused by
smoking
relative risk of passive smoking
1.25
3 other causes of lung cancer
radon
asbestos
chromates
where does radon naturally occur
soil and rocks
highest rates of radon in the UK
cornwall
3 occupations with increased risk of radon
aircrew
nuclear fuel plant
power station workers
3 properties of a maligant neoplasm
excessive growth
local invasiveness
ability to metastasise
3 indirect actions of carcinogens
induction of chronic inflammation
hyperplasia
metaplasia
what are mutations called that are essential for tumour cell survival
driver mutations
how many carcinogens in cigarette smoke
43