L6 MHC Locus - Hudig

Question 1

What two proteins make up the MHC I ?

Answer 1

MHC I alpha and B2microglobulin

Question 2

is B2microglobulin coded with MHC?

Answer 2

no, gene is outside MHC complex

Question 3

What proteins make up the MHCII?

Answer 3

MHCII alpha and beta chains

Question 4

Are CD proteins coded with MHC?

Answer 4

NOOPE, on a different chromosome

Question 5

HOw many alleles of MHC does each person have?

Answer 5

2

Question 6

is MHC inherited with crossing over?

Answer 6

NO

Question 7

How many loci are there for MHCI? what are they called?

Answer 7

3; a, b, and c

Question 8

How many loci are there for MHCII? What are they called?

Answer 8

3; DP, DQ, AND DR

Question 9

what sets DR apart from DQ and DP?

Answer 9

It encodes two beta chains and one alpha chain instead of one each

Question 10

Distinguish between multi-allelic and multigenic?

Answer 10

multigenic= three genes come together to make MHC
multiallelic:= there are multiple variants of each of the three genes

Question 11

which MHC I gene has the most alleles?

Answer 11

b

Question 12

What is the pattern of MHC gene and allele expression?

Answer 12

both are codominant

Question 13

How many different MHC I proteins will there be on a cell of a completely heterzygous person?

Answer 13

6

Question 14

What cells would present with six types of MHCI?

Answer 14

all cells except APCs and RBCs

Question 15

MHCI (blank) maximizes the antigenic peptide presentation in humans

Answer 15

allelic variation

Question 16

Is it the way the proteasome degrades foreign peptides or MHCI construction that dictates antigen presentation?

Answer 16

MHCI construction, proteasome cuts the same protein up the same in everyone

Question 17

Each memory CTL needs a match of the same peptide in the (same/any) MHC I (that fits into its TCR) to kill

Answer 17

SAME PEPTIDE IN SAME MHCI, NEEDS TO BE FUCKING IDENTICAL

Question 18

What do you must have to test CTL anti-viral vaccines?

Answer 18

target cells of the SAME MHCI as the immune donor of the CTLs

Question 19

Which MHC is inducible on endothelial cells during inflammation?

Answer 19

MHCII

Question 20

MHC class II allelic polymorphism means that some individuals will be (more/less) able to respond to some pathogens

Answer 20

LESS :(

Question 21

WHat cells lack both MHCI and II?

Answer 21

RBCs

Question 22

Neutrophils strongly express which MHC?

Answer 22

MHCI

Question 23

Which cells express both MHCI and MHCII?

Answer 23

APCs, macrophages, Bcells, and *occasionally T cells

Question 24

organ specific cells express MHCI or II?

Answer 24

MCHI

Question 25

What is relative risk?

Answer 25

is the incidence of the disease in individuals bearing the MHC locus/divided by the incidence in the population of individuals lacking the allele.

Question 26

What happens when preproinsulin binds to DR3, DR4, or DQ8 MHC proteins?

Answer 26

These MHC-peptides are selectively recognized by IDMM Type I immune patients. These anti-self T helpers could then support development of CTL anti-pancreatic beta cell killer cells.

Question 27

what is the order of importance when looking at barriers to transplantation?

Answer 27

1. ABO BLOOD GROUP 2. HLA class II 3. HLA class I 4. minor histocompatibility Ags

Question 28

What is an autograft?

Answer 28

tissue grafted from the same person OR between two genetically IDENTICAL people

Question 29

What is an allograft?

Answer 29

grafted between HLA and other loci ALLOGENIC individuals

Question 30

How quickly are allografts rejected?

Answer 30

within two weeks without immunosuppresion

Question 31

What is the result when transplant patients are MHC haplotype matched?

Answer 31

better survival and health

Question 32

Is there any way to have an organ transplant without immunosuppresion?

Answer 32

get your unfortunate twin to cough an organ up fer ya

Question 33

Can you still have graft rejection even with complete HLA matching?

Answer 33

yes

Question 34

Do T cells respond with greater frequency to foreign MHC molecules or to self MHC bearing an Ag?

Answer 34

Respond more to foreign MHC (1/100 tcells) while self mHC + Ag (1/1million t cells)

Question 35

MHCIII genes are non (blank)

Answer 35

allellic

Question 36

Haplotypes are linked sets of genes inherited as a (blank)

Answer 36

unit

Question 37

How many MHC haplotypes do you get from each parent?

Answer 37

one

Question 38

What bug produces super Ags?

Answer 38

staphylococci, staph aureus, including MRSA

Question 39

What makes something a super Ag?

Answer 39

they bind to a large number of t cells and trigger MASSIVE t cell response

Question 40

What about their binding pattern makes things super Ags?

Answer 40

they bind to the MHCII and TCR Vbeta receptor simultaneously

Question 41

Do superAgs bind in the MHCII binding groove?

Answer 41

no

Question 42

what are two diseases associated with super Ags?

Answer 42

toxic shock syndrome and food poisoning

Question 43

Can a super ag bind to any TCR Vbeta?

Answer 43

No, only specific ones

Question 44

What percent of T cells can a given super Ag bind to?

Answer 44

2-20%

Question 45

What does IL1 do systemically?

Answer 45

release of pyrogens and create a fever

Question 46

What happens after exposure to enterotoxins?

Answer 46

acute diarrhea