L5: lymphoid anatomy Flashcards
what are primary and secondary lymphoid tissues
primary = where BandT cells develop = thymus and bone marrow
secondary = where lymphocytes migrate to = lymph nodes, spleen, MALT
what do lymphoid vessels contain
lymph fluid
lymphocytes
tissue dendritic cells
what enters via afferent lymphatic
antigen loaded dendritic cells or macrophages
where do b cells proliferate in an infection
germinal centre of secondary follicle
where are t cells in the lymph node
paracortex
3 types of Mucosal associated lymphoid tissues (MALT)
gut (GALT)
Nasal (NALT)
bronchus (BALT)
what specific parts of body are MALT
tonsils
appendix
peyers patches in gut
what do mucosal cells allow
antigens to transit from gut lumen into lymphoid structures (peyers patches)
where does the spleen filter antigens from
blood via arteires (NO afferent lymphatics)
what is periarteriolar lymphoid sheaths (PALS)
portion of the white pulp of the spleen containing lots of T cells
surround the red pulp of the spleen
major lymphatic vessel that drains into blood
thoracic duct
what do high endothelial venules allow
the lymphocutes leave bloodstream and enter lymph node
what 2 main things direct lymphocyte migration
adhesion molecules
chemokines
where is the adhesion molecule L-selectin expressed and what is its ligand
all types of leukocytes
cd34
what is CR3 adhesion molecule expression on and what is its ligand
monocytes, neutrophils, macrophages
ICAM-1 ligand
