L4- intestinal SCN Flashcards
how long does it take for the cells to migrate from the crypt to the top of the villi
3-5 days
eptihelial cell types in the villi
goblet cells pareth stem cells absorptive enteroendocrine
what give rise to all cell types in the villi
multipotent stem cells at the crypt
what are the consequences when the SC dont self renew
SC population will be depleted and exhuasted
what are the consequences if theres too much of SCs
compromises functionality of the tissue or the organ
content : SC cells can choose between self renewal and differentaiton
to maintain the balance between those two
how do Stem daughter cells choose between self renewal and differentiation
localised determinants and signals from the neighbouring cells ( the 4 signalling pathways?)
4 types of signalling that regulate the SCN
- paracrine
-juxtacrine
endocrine
autocrine
what is juxtacrine signalling (JS)
-direction interaction between two cells through the receptors
what mediates the JS
notch pathway
what is notch
cell surface protein on a cell
-
notch binds to what
delta or serrate on other cell
- when its activated, blocks the specialisation of the SC and maintain the pluripotency
what kind of cell express delta
paneth
what is paracrine signalling
releasing molecules (morphogen) creating conc gradient - that gradient contributes to different fates of the cells achieved
what is Wnts and its function
a morphogen > maintaining the gut-stem cell compartment
