L4 Comparative Bacterial Genomics Flashcards
Comparing the genomes of bacteria to understand common ancestry and functions
Define: Genome
The sum of the genetic information in an individual organism 🐕
Define: Genomics
The acquisition, storage, retrieval and analysis of DNA sequence data 📊
The size of genome generally reflects organism lifestyle. Smaller genomes tend to be from…
Symbiotes and organisms living in specific environments
In E.Coli there are 2 replication forks starting at X and ending at Y
X: oriC
Y: terC
The mean generation time of E.Coli is…
20 minutes ⏰
⏳The mean generation of E.coli is shorter than the time it takes to replicate the chromosome. This is because…
Replication is continuous and may start again on the new chromosome strand, even before it has finished replicating
Genes of related function often…
Cluster together
Streptomyces coelicolor has a ? chromosome.
Linear
The Streptomyces coelicolor chromosome has a ‘core’ and two more variable terminal regions known as …
‘Arms’
Areas of matching genes between two organisms are known as regions of…
Syntony
An X shape between two sequences in the analysis software suggests the same genes are present, but in a reversed order. This is the result of an…
Inversion event
A V shape between two sequences in the analysis software, with certain genes present in one sequence but not the other, may suggest…
Horizontal gene transfer
Metagenomics is the study of genetic material…
Recovered from environmental samples
Metagenomics has made useful contributions to our understanding of…
Microbiomes
