L4 Flashcards
1
Q
what is meant by “normal” as in “normal Myc”
A
untransformed
2
Q
FBS
A
blood plasma from cow - full of liquid with growth factosr
3
Q
what happens if you add FBS to normal cells
A
signal to proliferate
4
Q
3 ways Myc could be deregulated
A
- level just flat but always on
- follows normal pattern but higher or lower
- longer half life,
5
Q
what kind of mutations often change protein protein interactions, stability, etc
A
mutations involving PTM regions
6
Q
5 types of photo-oncogene activations
A
- coding mutation
- regulatory mutation
- translocation
- gene amplification
- deregulation of upstream patwhay
