L3 Renal Clearance

Question 1

How do you calculate FLx?

Answer 1

FLx= (GFR) (Px)

Question 2

How do you calculate excretion rate?

Answer 2

ER= Ux(V) OR ER= FLX + Sx - Rx

Question 3

What are the algorithms for estimating GFR based on plasma creatinine?

Answer 3

Cockcroft-Gault, MDRD 4, and CKD-EPI

Question 4

What is the clearance equation?

Answer 4

Cx= (Ux x V)/ Px

Question 5

Clearance of a secreted substance will be ** than Ccr, thus ** than GFR.

Answer 5

Greater, greater

Question 6

Clearance of a reabsorbed substance will be ** than Ccr, thus ** than GFR.

Answer 6

Less, less

Question 7

What does a clearance ratio of 1 mean?

Answer 7

The substance must be a GFR marker (filtered, but neither secreted or reabsorbed)

Question 8

What does a clearance ratio of less than 1 indicate?

Answer 8

Either the substance is not filtered, or it is filtered and reabsorbed

Question 9

What does a clearance ratio of greater than 1 indicate?

Answer 9

The substance is filtered and secreted

Question 10

Clearance of PAH is an estimate of what?

Answer 10

RPF

Question 11

How are Creatinine and GFR related?

Answer 11

Inversely. As Creatinine increases, GFR decreases