Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Y4R8 - Surgery III👨‍⚕️ > L3: Breast Cancer - Pt 5 > Flashcards

L3: Breast Cancer - Pt 5 Flashcards

1
Q

TTT of Stage III Breast Cancer

  • Outlines
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chemotherapy in TTT of Breast Cancer

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Chemotherapy in TTT of Breast Cancer
- Overview

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chemotherapy in TTT of Breast Cancer

  • Neo-adjuvant
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Neo-adjuvant Chemotherapy in TTT of Breast Cancer
- Advantages

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Neo-adjuvant Chemotherapy in TTT of Breast Cancer

  • Disadvantages
A
  • Inadequate downstaging
  • Chemoresistance
  • Undertreatment
  • Overtreatment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Neo-adjuvant Chemotherapy in TTT of Breast Cancer
- Indications

A

In-Opearble Breast Cancer

  • Bulky N2, N3 nodal disease
  • T4 disease
  • IBC

Opearble Breast Cancer

  • Worse prognostics molecular subtypes (HER2 + or TNBC).
  • Patient desire breast conservation with large tumor to breast ratio
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adjuvant Chemotherapy in TTT of Breast Cancer
- Indications

A

Indications (6 weeks after surgery):

1. Triple negative & HER-2 positive:

if:
- T size >0.5 cm
- N+ve regardless T size

2. HR +Ve or HER2-ve:

if
- N +ve
- high-risk patients with node -ve disease (high
grade, young patient, positive family history, + LVI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chemotherapy in TTT of Breast Cancer

  • Protocols
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chemotherapy in TTT of Breast Cancer

  • SE
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SE of Anthracyclines

A

cardiotoxicity, secondary leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

SE of Taxanes

A

neuropathy, hypersensitivity reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SE of Trastuzumab/pertuzumab

A

cardiotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SE of Tamoxifen

A
  • endometrial cancer
  • venous thromboembolism
  • cataracts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SE of Aromatase inhibitors “Femara

A

decreased bone mineral density

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hormonal Therapy in Breast Cancer

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Hormonal Therapy in Breast Cancer

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Hormonal Therapy in Breast Cancer

  • Indications
A
  • Skeletal metastasis
  • ER +ve
  • Slow course
  • unfit patient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Hormonal Therapy in Breast Cancer

  • Technique
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Technique of Hormonal Therapy in Breast Cancer

  • Ablative (surgical)
A
  • Bilateral oophorectomy (resection or irradiation)

Indicated In: Only in premenopausal or 5
years postmenopause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Technique of Hormonal Therapy in Breast Cancer

  • Additive (medical)
A
  • Tamoxifen “1st Line”
  • LH/RH agonists
  • Aromatase enzyme inhibitors
  • SERD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Additive (Medical) Hormaonal TTT of Breast Cancer

  • Tamoxifen (Examples, Dose, SE)
  • Raloxifen
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Additive (Medical) Hormaonal TTT of Breast Cancer

  • LH/RH agonist
A

(Zoladex / goserlin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Additive (Medical) Hormaonal TTT of Breast Cancer

  • Aromatase enzyme inhibitors
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Aromatase enzyme inhibitors in TTT of **Breast Cancer** - Drugs
- (Aminoglute themide) - (Femara/anastrazol)
26
Aromatase enzyme inhibitors in TTT of **Breast Cancer** - Mechanism
27
Aromatase enzyme inhibitors in TTT of **Breast Cancer** - Indications
- Post-menopausal - Low grade - HR-positive - HER2 -ve disease
28
Hormonal Therapy in TTT of **Breast Cancer** - Protocols acc to age
**Pre-menopausal:** Tamoxifen then LHRH agonists then oophorectomy **Post-menopausal:** Aromatase Inhibitors then Tamoxifen then progestagens
29
Hormonal Therapy in TTT of **Breast Cancer** - SERD
Fulvestrant
30
Radiotherapy in **Breast Cancer**
31
Radiotherapy in **Breast Cancer** - Techniques
- **External radiation:** 5000 rad 5 days/week over 5 weeks (25 sessions) - **Partial breast irradiation (PBI):** if negative axilla
32
Radiotherapy in **Breast Cancer** - Indications
▪ All BCS ▪ Post mastectomy - T3 (1ry tumor > 5 cm) - Node + (>4 LN ) - +ve safety margin or <1mm
33
Target Therapy in **Breast Cancer** - Indications
Her2/neu +ve
34
Target Therapy in **Breast Cancer** - Examples
Herceptin “Trastuzumab”, Pertuzumab (Perjeta)
35
ImmunoTherapy in **Breast Cancer** - Indications
high risk TNBC with chemotherapy
36
ImmunoTherapy in **Breast Cancer** - Examples
Pembrolizumab
37
Adjuvant bisphosphonates in **Breast Cancer** - Indications
bone stabilizer and risk reduction of mets
38
Adjuvant bisphosphonates in **Breast Cancer** - Examples
Zoledronate “Zometta”
39
Pathological complete Response - Def
Absence of invasive disease in breast & LN
40
**Pathological complete Response** - Incidence
41
**Pathological complete Response** - US Guided Clipping
- US guided Clipping is used before receiving Neoadjuvant to help localize the tumor site after complete response to facilitate BCS
42
TTT of **Stage IV Breast Cancer**
43
TTT of **Stage IV Breast Cancer** - Systemic
As before + - CD4/6 inhibitors - mTor inhibitors - PARP inhibitors - Immunotherapy
44
TTT of **Stage IV Breast Cancer** - Palliative
▪ Toilet mastectomy ▪ Laminectomy or vertebroplasty -----> Bone metastasis ▪ Pleurodesis ----> pleural effusion
45
Bernard Fissure’s theory
**Breast cancer is a systemic disease from the start, as it spreads so early by blood micrometastases**
46
Prognosis of **Breast Cancer** - Nottingham Prognostic Index
(0.2 x size of tumor in cm) + Grade + Lymph node status
47
Prognosis of **Breast Cancer** - Factors
- Patient & Tumor Related
48
Prognosis of **Breast Cancer** - Patient-Related Factors
49
Patient-Related Factors in Prognosis of **Breast Cancer** - Age
50
Patient-Related Factors in Prognosis of **Breast Cancer** - sex
51
Patient-Related Factors in Prognosis of **Breast Cancer** - Pregnancy
52
Patient-Related Factors in Prognosis of **Breast Cancer** - Obesity
53
Prognosis of **Breast Cancer** - Tumor-Related Factors
54
Tumor-Related Factors in Prognosis of **Breast Cancer** - LN
55
Tumor-Related Factors in Prognosis of **Breast Cancer** - Site
Worse prognosis in lower inner quadrant
56
Tumor-Related Factors in Prognosis of **Breast Cancer** - Size
The bigger, The Worse
57
Tumor-Related Factors in Prognosis of **Breast Cancer** - Mets
Markedly worse prognosis in Presence of distant metastases
58
Tumor-Related Factors in Prognosis of **Breast Cancer** - Skin & Nipple Invasion
Worse prognosis in skin & nipple invasion
59
Tumor-Related Factors in Prognosis of **Breast Cancer** - Staging
Worse prognosis in Stage V than stage IV
60
Tumor-Related Factors in Prognosis of **Breast Cancer** - Pathological Types
61
Tumor-Related Factors in Prognosis of **Breast Cancer** - Pathological Types (Bad)
▪ Infiltrating duct carcinoma. ▪ Mastitis carcinomatosis (worst) ▪ Paget’s with mass ▪ Signet ring
62
Tumor-Related Factors in Prognosis of **Breast Cancer** - Pathological Types (Better)
▪ Medullary type ▪ Mucinous type ▪ Tubular type ▪ Lobular type ▪ Papillary type ▪ Paget’s without mass

Y4R8 - Surgery III👨‍⚕️ (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions