L3: Breast Cancer - Pt 2 Flashcards
1
Q
Infiltrating Carcinoma
A
- Ductal cancer cells breakthrough the wall
- The cancer has spread to the surrounding tissues
2
Q
Types of Infiltrating Carcinoma
A
3
Q
Types of Infiltrating Carcinoma
- IDC
A
Prognosis: 70%, Moderate
4
Q
Types of Infiltrating Carcinoma
- ILC
A
- Multicentricity, Bilaterality in 50%
- Prognosis: Better “Hormone dependent”
5
Q
Types of Infiltrating Carcinoma
- Medullary “Encephaloid”
A
- Soft, Brain like appearance, Lymphocytes
- Prognosis: Good “The best after Tubular”.
6
Q
Types of Infiltrating Carcinoma
- Mucinous “Colloid”
A
- Honeycomb appearance, Soft, Mucin,
- Prognosis: Good
7
Q
Types of Infiltrating Carcinoma
- Mastitis Carcinomatosis
A
- Diffuse brawny induration, Non pitting edema >1/3 breast, no palpable mass, by lymphatic embolization
- Prognosis: Very bad
- DD: Acute breast abcess (Acute, rapid, fever, pitting edema & tenderness)
8
Q
Types of Infiltrating Carcinoma
- Tubular
A
Prognosis: The best
9
Q
Types of Infiltrating Carcinoma
- Papillary
A
Prognosis: Good
10
Q
Types of Infiltrating Carcinoma
- Paget’s Disease of The Nipple
A
11
Q
Types of Infiltrating Carcinoma
- rare Types
A
12
Q
Types of Infiltrating Carcinoma
- Molecular Types
A
13
Q
Compare Between Mastitis Carcinomatosa & Acute Abscess in terms of
- Onset
- Course
- Fever
A
14
Q
Compare Between Mastitis Carcinomatosa & Acute Abscess in terms of
- Edema
- Skin
A
15
Q
Compare Between Mastitis Carcinomatosa & Acute Abscess in terms of
- Tenderness
- Edema
- Axillary LN
A
16
Q
Compare Between Mastitis Carcinomatosa & Acute Abscess in terms of
- INVx
A
17
Q
Compare Between Mastitis Carcinomatosa & Acute Abscess in terms of
- TTT
A
18
Q
Types of Carcinoma NOS
A
- Scirrhous
- Atrophic scirrhous carcinoma
19
Q
Scirrhous Carcinoma NOS
- Incidence
- Characters
- NE
- ME
- Prognosis
A
20
Q
Atrophic scirrhous carcinoma
A
21
Q
Invasive Lobular Carcinoma
- Incidence
- Multicentricity
- NE
A
22
Q
Medullary Carcinoma
- Incidence
A
4%
23
Q
Medullary Carcinoma
- NE
A
24
Q
Medullary Carcinoma
- ME
A
25
**Medullary Carcinoma**
- Prognosis
Good
26
**Mucinous Carcinoma**
- Incidemce
2%
27
**Mucinous Carcinoma**
- Behaviour
Slowly growing tumor
28
**Mucinous Carcinoma**
- NE
29
**Mucinous Carcinoma**
- ME
30
**Mucinous Carcinoma**
- Prognosis
Good
31
**Tubular Carcinoma**
- Incidence
Uncommon - Late 40 s
32
**Tubular Carcinoma**
- Morphology
33
**Tubular Carcinoma**
- Receptors
34
**Tubular Carcinoma**
- Radiology
Small irregular mammographic densities
35
**Tubular Carcinoma**
- Prognosis
Excellent
36
**Papillary Carcinoma**
- NE
When lactiferous duct is opened → a pedicle arising from duct wall with small finger like processes passing to smaller ducts which are dilated
37
**Papillary Carcinoma**
- ME
Fibro vascular core with finger like processes covered by several layers
38
**Papillary Carcinoma**
- Prognsosis
Good
a) Early presentation by alarming bleeding.
b) Slow rate of growth
c) Late spread
39
**Mastitis carcinomatosa**
- NE
- ME
- Prognosis
- DDx
40
**Paget Disease of The Breast**
- Incidence
- Etiology
41
**Paget Disease of The Breast**
- Detected By
Paget cells readily detected by nipple biopsy or cytologic preparations of exudate
42
**Paget Disease of The Breast**
- CP
43
**Paget Disease of The Breast**
- ME
Usually poorly differentiated, ER negative, and overexpress HER2/neu.
44
**Paget Disease of The Breast**
- Prognosis
- Depends on the features of the underlying carcinoma
- Not affected by presence or absence of DCIS involving the skin when matched for other prognostic factors.
45
Spread of **Breast Cancer**
46
Spread of **Breast Cancer**
- Direct
47
Spread of **Breast Cancer**
- Lymphatic
48
Spread of **Breast Cancer**
- Blood
49
Spread of **Breast Cancer**
- Transcelomic
50
Skin Manifestations of **Breast Cancer**
- Due to Direct infiltration
- Due to Lymphatic infiltration
- Due to Venous infiltration
51
Skin Manifestations of **Breast Cancer**
- D2 Dirsect Infiltration
52
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
53
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Skin dimpling, Tethering & Puckering
54
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Dimpling
55
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
-Tethering
56
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Puckering
57
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Skin fixation, ulceration & fumigation.
...
58
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Nipple retraction
Due to infiltration and fibrosis of the main milk ducts.
59
Skin Manifestations of **Breast Cancer** Due to Direct Infiltration
- Paget's disease of nipple:
see before
60
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
61
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
- Peau d'orange
62
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
- Cancer en Cuirasse
63
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
- Cancerous satellite nodules
64
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
- Mastitis carcinomatosa
It is due to tumor embolization of dermal lymphatics
65
Skin Manifestations of **Breast Cancer** Due to Lymphatic Infiltration
- Malignant Edema of UL
66
Skin Manifestations of **Breast Cancer** Due to Venous Infiltration
- Dilated veins: Due to venous obstruction >> superficial thrombophlebitis >> Mondor’s disease
