L3 Flashcards
Loading and unloading phase
Loading: plateau
Unloading: steep region
Shifts curve right
Increase temp
Increase CO2
Increase H
Increase 2,3 DPG
Normal values for Hb
15 grams
Normal values for O2
20ml/100ml blood
Forms of CO2
dissolved: 7%
Hb bound: 23%
HCO3 (70%)
CO2 binds to form
Carbaminohemoglobin
Binds to heme portion, no competition with oxygen
CO binds to form
Carboxyhemoglobin
Carbonic anhydrase
What does it do
Where is it found
Catalyzes the formation of carbonic acid
Found in erythrocytes not plasma
Reaction acidifies the plasma
H binding
binds to histidine residues
Affinity depends on Po2 (Inverse)
How is H transported
Hb picks up H in tissues to minimize HCO3 effects on ph
Hb releases H in lungs to combine with HCO3 and CA runs reverse reaction