L12 GI Flashcards
Four main hormones in digestion
Gastrin
Cholecystokinin
Secretin
Glucose dependent insulinotropic peptid
Phases of GI
Cephalic
Gastric
Intestinal
Cells of gastric pit
Mucous neck cells
Chief cells
Parietal cells
Glandular areas
Oxyntic:body and fundus
Pyloric: antrum
HCl secretion
Parietal cells in fundus and body
Intrinsic factor secretion
Parietal cells in fundus and body
Pepsinogen secretion
Chief cells in body and antrum
Secretion of HCl
CO2 H2O CA make HCO3 and H
Cl in, HCO3 out (blood)
Hout/Kin atpase
Clout, combines with H in lumen
Inputs to parietal cells for HCl
Histamine is strongest
Gastrin and Ach trigger Histamine and have direct effects
Somatostatin mechanism
Secreted by D cell
inhibits gastrin by G cell (histamine indirectly)
Inhibits Parietal cell directly
When Chyme drops below pH 3, what happens
Secretin is produced
Enterogastrones
Secretin and CCK
Inhibit secretion and motility in stomach
CCK is stimulated by and leads to
amino acids
Fatty acids
Leads to Pancreas enzymes
Bile flow from gallbladder
Secretin is stimulated by and leads to
High H+
Leads to pancreas HCO3
Peristalsis is driven by
myoelectric complex
Motilin hormone