L21: How Do You Know A Treatment Is Working Flashcards
What are the current treatments for cancer
Surgery Chemotherapy Radiotherapy Hormone therapy Immunotherapy Biological therapies
What is the 3 aims of all treatment types
1) remove all cancer cells to cure patients
2) kill most cancer cells to prolong survival in advanced cancer
3) kill some cancer cell to palliate symptoms
What is relapse
If the cancer cells grow again
What is a tumour response
When treatment works to reduce the size of the tumour
What does the tumour response not indicate
That the survival rate is increasing
How do we measure the tumour response
With a method called RECIST
What does RECIST stand for
Response evaluation criteria in solid tumours
What are the 2 responses in RECIST
Target lesions response
Non target lesions response
What are target lesions
These are measurable lesions
What are non target lesions
Lesions that we cannot measure, you can only look at it qualitatively
What are the 4 responses with target lesions
Complete response
Partial response
Progressive disease
Stable disease
What is the criteria for a complete response
All target lesions have disappeared
What is the criteria for partial response
A reduction of the sum of diameters by at least 30%
What is the criteria for progressive disease
An increase in the sum of diameter of target lesions by 20%
What is the criteria for stable disease
No significant change
What are the 3 responses for a non target lesion
Complete response
Non complete non progressive disease
Progressive disease
What is the criteria for a compete response
Disappearance of all non target lesions
What is the criteria for non complete response/ non progressive disease
Persistence of one or more non target lesions
What is the criteria for a progressive disease in non target lesions
Progression of existing non target lesions
What are the 3 survival times
Overall survival time
Disease free survival time
Progression free survival time
What is the overall survival time
The time from treatment to time of death
What is the disease free survival time
Time before the relapse of the tumour after a treatment before it comes again
What is the progression free survival time
Tumours is still evident but you have stopped it from progressing
What is a clinical trial
An experiment that involves patients to determine future treatment