L14 Flashcards
hepatitis b clinical sign
not spesifik
jaundice, dark urine, clay color stool
hepatomegaly
akut hepatitis B
iasanya di bayi, gaada manifestasi klinis
makin tua makin kelihatan symotomnya
hepaiti B kronis
punya hbs Ag leih dari 6 bulan
kebanyakan lifelong
symptom hepatitis b kronis
..
epidemiologi hbv
most common
mayoritasa asia afrika
seroprevalence HBsAg
high: subsahara afrika, east asua, pasifik silanda, amaon basin
tengah central america, nort aerica, west eropa
transmisi hbv
vertikal, horiontal
vertical transmission
HBeAg +, transmisi 90%
HBsAg + HBeAg - : 10%
horizontal
sexual intercouse, pemakaian jarum suntik bersama
feature of hepatitis b virus
envelope
nukleotida
one partial dsDNA
core protein (HcAg)
hepatitis e antigen (HBeAg)
dna pol
S protein gene dimana
large orf
selain produksi virior, host juga akan produksi
subviral particles
subviral partikel tu
host derived lipoportein
envelope glyco protein
subviral: viral
1000-10.000:1
fungsi subviral particle
proteksi viral particle dari antibodi
subtipe virus hepatitis b
ga pengaruh ke imunologi, kalo terinfeksi 1 maka yg lain juga bisa imun
korelasi viral load?
gada korelasi dgn severity
korelasi severity dgn
repon host cell
HBsAg +
infectiors
anti Hs Antibody +
imuniyas
HBeAg+
highly infectious
antiHBe +
mau selese infeksinya
hepatitis C virus epidemiology
worldwide
before scrrening of blood: transfusion associated
diatas 15 th
reinfeksi?
yes. abis terinfeksi ga njamin ada imunitas
virion morphology HCV
spike like projection
genom: plus tsrand RNA
genom HBC
heterogen,
no serotypic classif
atogenesi mengenai kesembuhan
30%
70%
15-30% dari kronic hcv cirrhosis
HCC mechanism
unknown
reinfection?
yes
marker hcv
HCV Ab denan 2nd 3rfELISA, se
..?
hepatitis d
blood borne dlm etuk viroid
genom
ssRNA viroid, deivut delta agent
defective viru, gmn
gabisa infeksi sendirian. aru bisa ineksi kalo bersama HBV
kenapa defective
perlu HBsAg coating baru bisa infeksi