L13 - Acute and chronic inflammation of the GIT

Question 1

What are the different types of diarrhoea?

Answer 1

1. Secretory
2. Hypermotility
3. Defective ion transport
4. Osmotic

Question 2

What is the cause of secretory diarrhoea?

Answer 2

• Small intestinal secretions overwhelm capacity for colonic reabs
• Toxins result in INC cAMP and thus secretion
• Oral rehydration therapy needed

Question 3

What is the cause of hypermotility diarrhoea?

Answer 3

• Inc motility results in inc water and electrolytes delivered to the colon

Question 4

What is the cause of defective ion transport diarrhoea?

Answer 4

• Na+ transport non-functional
• Bile acids in colon/ fat malabs
• Chloridorrhoea

Question 5

What is the cause of osmotic diarrhoea?

Answer 5

• Hypertonic fluid in intestinal lumen
• Abs disorders can results in osmotic diarrhoea
• Microbial fermentation then worsens

Question 6

What is acute inflammation?

Answer 6

Short term process occurring in response to tissue injury, usually appearing within minutes or hours
- Characterised by 5 cardinal signs

Question 7

What are the 5 cardinal signs of acute inflammation?

Answer 7

• Redness
• Inc heat
• Tumour (swelling)
• Dolor (pain)
• Loss off function (immobility)

Question 8

What is the most common symptom of acute inflammation?

Answer 8

Diarrhoea

Question 9

What therapy could be given to mild traveller’s tummy?

Answer 9

1. Loperamide/ BSS

2. Azithromycin

Question 10

What therapy could be given to severe traveller’s tummy?

Answer 10

1. Antibiotics

2. Azithoromycin