L10- schiz Flashcards
what is schiz
divided mind
severe psychritic disorder
distortion of thoughts, perception and mood
ways that schiz is displayed
- repeated eps of psychitic actions
- chronic eps leading to progressive decline
what are positive symptoms (type 1) and egs
presence of abnormal thoughts and behaviour
- delusion
halluncinations
disorganised speech
what are negative symtopms (type 2) and egs
absense of normal reposnses or behaviours
- reduced expresion of emotions
social withdrawal
aetiology
- genetic
- slow viral infection
- associated autoimmune process
- poor maternal nutrition
- development abnormality
dopamine hypothesis for schiz
dopa hyerpactivity leads to schiz, type 1 symptoms
evidence for dopa hypothesis
- amphetamine drug > dopa releasing drug
- dopa D2 receptor agonists> increase dopa concs
- too much L-dopa
what are neuroleptics
antischiz drugs
- tranquilisers
types of neurolpetics
typical and atypical
3 main classes of typical neuroleptics
phenothiazines
butyrophenones
thioxanthenes
mechanism of typical neuroleptics
- blocks receptors including D2 and D1 receptors
- muscarinic R for ACH
- H1 R for histamine
- a adrenoreceptors for NA
differences between typical and atypical
atypical:
- higher D R selectivity
- reduce side effects
- more effective against negative symtopms
- more effective against treatment resistant schiz
typical
-reduce pos symptoms
eg of atypical symptoms
selective dopamine receptor antagonists
- multi acting receptor targetd antagonists
- serotonin -dopamine antgonsist
dopamine pathways relating to schix
mesocortical and mesolimbic
what is thought about mesocortical pathway
hypofunction of this causes -ve symtopms
