L10. mycobacteria Flashcards
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what is the target cell to infect for mycobacteria?
in alveolar macrophages
what is the moa of mycobacteria?
teh response to mycobacteria by immune system causes the disease
how do we refer to mycobacteria that does NOT cause TB?
Atypical mycobacteria/ MOTT…
how doe we refer to mycobacteria that cause leprosy??
xx
what is the most common infection caused by mycobacteria?
TB
what is the second most caused infection by mycobacteria>
leprosy..
what are the four groups of NT - MOTT? (runyon classification)
1.slow growing …
2.
3.
4.
what is the prevalence of mycobacteria infection?
one third of the population
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what is the difference b/w infection and disease?
infection - not necessarily disease
how is TB transmitted?
aerosol transmission: after sneezing the mycobacteria stay in “clouds” of air
droplet vs aerosol transmission
droplet -
aerosol -
what is the pathogenesis of pulmonary TB?
intracellular multiplication - alveolar …macrophages
what is caseation?
cheese in lungs…
what is the most common cause of addisons diseaase?
x
what is pott’s disease?
x
what is skin TB?
lupus….
x
IL 12 tnf alpha inf gammma
3 characteristics of tb??
langhans giant cells, caseous granulomas, epthilod…???
primary infection of tb called?
ghons focus
does ghons focus mean disease?
no?
x
night sweats, …
what are the x
tuberculin skin test and ifn gamma - exposre tessts
what are the disease Tb tests?
micrscopy and culture
What is tuberculin (PPD) skin test - TST
x
what is induration?
hard swelling
what is IGRA?
interferon gamma release assay
what are the antigens used for igra? (2)
esat - 6, cfp - 10
TST vs IGRA? (3)
x
what is a common urine contaminant during urine test (usually in men)?
mycobactera smegmatis…
what is auramine stain>?
x
what is cord factor?
mark of virulent mTB
skip lab diagnosis
x
what media is required to grow TB?
L -J media
whatis the apperance of TB on l - j media?
rought tough…
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what are the challeneges of treatment (apart from non compliace?) (2)
x mdr …
what are the four drugs of TB?
isonia…
pan susceptible
tb is suceptible to all four drugs…
group A b C drugs?
x
…
….
what is DOT?
directly observed therapy - WHOs strategy to eradicate TB
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what is leprosy?
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what are the two different types of leprosys? (2)
x
can you culture m. leprae?
no
what is z - n smear?
…
what is leonine facies
x
m. avium and intercellular..
x
what is MAC? what are the diesease caused ? (3)
x
